2023

Merra A, Maurizi E, Pellegrini G. Impact of culture media on primary human corneal endothelial cells derived from old donors. Exp Eye Res. 2024 Feb 3;240:109815. doi: 10.1016/j.exer.2024.109815. Epub ahead of print. PMID: 38316204.

Genna VG, Adamo D, Galaverni G, Lepore F, Boraldi F, Quaglino D, Lococo F, Pellegrini G. Validation of airway porcine epithelial cells as an alternative to human in vitro preclinical studies. Sci Rep. 2023 Sep 28;13(1):16290. doi: 10.1038/s41598-023-43284-7. PMID: 37770485; PMCID: PMC10539525.

Attico E, Galaverni G, Torello A, Bianchi E, Bonacorsi S, Losi L, Manfredini R, Lambiase A, Rama P, Pellegrini G. Comparison between Cultivated Oral Mucosa and Ocular Surface Epithelia for COMET Patients Follow-Up. International Journal of Molecular Sciences. 2023; 24(14):11522. https://doi.org/10.3390/ijms241411522

Adamo D, Attico E, Pellegrini G. Education for the translation of Advanced Therapy Medicinal Products. Front Med (Lausanne). 2023 Apr 4;10:1125892. doi: 10.3389/fmed.2023.1125892. PMID: 37081845; PMCID: PMC10110892.

Polito MP, Marini G, Palamenghi M, Enzo E. Decoding the Human Epidermal Complexity at Single-Cell Resolution, Int. J. Mol. Sci. 2023, 24, 8544. https://doi.org/10.3390/ijms24108544.

Maurizi E, Merra A, Macaluso C, Schiroli D, Pellegrini G. GSK-3 inhibition reverts mesenchymal transition in primary human corneal endothelial cells. Eur J Cell Biol. 2023 Mar 7;102(2):151302. doi: 10.1016/j.ejcb.2023.151302. Epub ahead of print. PMID: 36905755.

De Luca M, Cossu G. Cost and availability of novel cell and gene therapies: Can we avoid a catastrophic second valley of death?: Can we avoid a catastrophic second valley of death? EMBO Rep. 2023 Jan 2:e56661. doi: 10.15252/embr.202256661. Epub ahead of print. PMID: 36592141.


2022

Barker RA, Carpenter M, Jamieson CHM, Murry CE, Pellegrini G, Rao RC, Song J. Lessons learnt, and still to learn, in first in human stem cell trials. Stem Cell Reports. 2022 Dec 14:S2213-6711(22)00552-5. doi: 10.1016/j.stemcr.2022.11.019. Epub ahead of print. PMID: 36563687.

Benati D, Leung A, Perdigao P, Toulis V, van der Spuy J, Recchia A. Induced Pluripotent Stem Cells and Genome-Editing Tools in Determining Gene Function and Therapy for Inherited Retinal Disorders. Int J Mol Sci. 2022 Dec 3;23(23):15276. doi: 10.3390/ijms232315276. PMID: 36499601; PMCID: PMC9735568.

Rontauroli S, Carretta C, Parenti S, Bertesi M, Manfredini R. Novel Molecular Insights into Leukemic Evolution of Myeloproliferative Neoplasms: A Single Cell Perspective. Int J Mol Sci. 2022 Dec 3;23(23):15256. doi: 10.3390/ijms232315256. PMID: 36499582; PMCID: PMC9740017.

Sceberras V., Magrelli F.M., Adamo D., Maurizi E., Attico E., Genna V.G., Lazzeri M., Barbagli G., Pellegrini G. The cell as a tool to understand and repair urethra – Chapter in Scientific Advances in Reconstructive Urology and Tissue Engineering. Elsevier. – ISBN: 9780323911993. 2022

Maurizi E, Martella DA, Schiroli D, Merra A, Mustfa SA, Pellegrini G, Macaluso C, Chiappini C. Nanoneedles Induce Targeted siRNA Silencing of p16 in the Human Corneal Endothelium. Adv Sci (Weinh). 2022 Nov;9(33):e2203257. doi: 10.1002/advs.202203257. Epub 2022 Oct 17. PMID: 36253148; PMCID: PMC9685449.

Cordella S, Parisotto A, Bettelli F, Morselli M, Barbieri E, Pozzi S, Aquilino A, Repaci G, Cuoghi A, Bresciani P, Messerotti A, Colasante C, Gilioli A, Pioli V, Giusti D, Colaci E, Cassanelli L, Ceccherelli G, Bevini M, Malavolti R, Venturelli D, Paolini A, Martinelli S, Maffei R, Riva G, Nasillo V, Trenti T, Comoli P, Tagliafico E, Manfredini R, Barozzi P, Potenza L, Marasca R, Luppi M, Forghieri F. Feasibility of autologous peripheral blood stem cell mobilization and harvest in adult patients with FLT3-mutated acute myeloid leukemia receiving chemotherapy combined with midostaurin: a single-center experience. Ann Hematol. 2023 Jan;102(1):213-217. doi: 10.1007/s00277-022-05013-4. Epub 2022 Oct 20. PMID: 36261597.

De Rosa L, Enzo E, Palamenghi M, Sercia L, De Luca M. Stairways to Advanced Therapies for Epidermolysis Bullosa. Cold Spring Harb Perspect Biol. 2022 Sep 27:a041229. doi: 10.1101/cshperspect.a041229. Epub ahead of print. PMID: 36167646.

Palamenghi M, De Luca M, De Rosa L. The steep uphill path leading to ex vivo gene therapy for genodermatoses. Am J Physiol Cell Physiol. 2022 Sep 1;323(3):C896-C906. doi: 10.1152/ajpcell.00117.2022. Epub 2022 Aug 1. PMID: 35912986.

Baldassarri S, Benati D, D’Alessio F, Patrizi C, Cattin E, Gentile M, Raggioli A, Recchia A. Engineered Sleeping Beauty Transposon as Efficient System to Optimize Chimp Adenoviral Production. Int J Mol Sci. 2022 Jul 7;23(14):7538. doi: 10.3390/ijms23147538. PMID: 35886882; PMCID: PMC9316264.

Maurizi E, Merra A, Schiroli D, Ghezzi B, Macaluso C, Pellegrini G. Fluctuations in Corneal Endothelial LAP2 Expression Levels Correlate with Passage Dependent Declines in Their Cell Proliferative Activity. Int J Mol Sci. 2022 May 23;23(10):5859. doi: 10.3390/ijms23105859. PMID: 35628669; PMCID: PMC9146651.

Attico E, Galaverni G, Bianchi E, Losi L, Manfredini R, Lambiase A, Rama P, Pellegrini G. SOX2 Is a Univocal Marker for Human Oral Mucosa Epithelium Useful in Post-COMET Patient Characterization. Int J Mol Sci. 2022 May 21;23(10):5785. doi: 10.3390/ijms23105785. PMID: 35628593; PMCID: PMC9144017.

De Rosa L, De Luca M. The joint battle to tackle epidermolysis bullosa through gene therapy. Trends Mol Med. 2022 Jul;28(7):533-535. doi: 10.1016/j.molmed.2022.05.001. Epub 2022 May 19. PMID: 35599142.

Chakravarti S, Enzo E, Rocha Monteiro de Barros M, Maffezzoni MBR, Pellegrini G. Genetic Disorders of the Extracellular Matrix: From Cell and Gene Therapy to Future Applications in Regenerative Medicine. Annu Rev Genomics Hum Genet. 2022 Aug 31;23:193-222. doi: 10.1146/annurev-genom-083117-021702. Epub 2022 May 10. PMID: 35537467.

Adamo D, Galaverni G, Genna VG, Lococo F, Pellegrini G. The Growing Medical Need for Tracheal Replacement: Reconstructive Strategies Should Overcome Their Limits. Front Bioeng Biotechnol. 2022 May 9;10:846632. doi: 10.3389/fbioe.2022.846632. PMID: 35646864; PMCID: PMC9132048.

Lagreca I, Riva G, Nasillo V, Barozzi P, Castelli I, Basso S, Bettelli F, Giusti D, Cuoghi A, Bresciani P, Messerotti A, Gilioli A, Pioli V, Colasante C, Vallerini D, Paolini A, Maccaferri M, Donatelli F, Forghieri F, Morselli M, Colaci E, Leonardi G, Marasca R, Potenza L, Manfredini R, Tagliafico E, Trenti T, Comoli P, Luppi M. The Role of T Cell Immunity in Monoclonal Gammopathy and Multiple Myeloma: From Immunopathogenesis to Novel Therapeutic Approaches. Int J Mol Sci. 2022 May 8;23(9):5242. doi: 10.3390/ijms23095242. PMID: 35563634; PMCID: PMC9104275.

Enzo E, Cattaneo C, Consiglio F, Polito MP, Bondanza S, De Luca M. Clonal analysis of human clonogenic keratinocytes. Methods Cell Biol. 2022;170:101-116. doi: 10.1016/bs.mcb.2022.02.009. Epub 2022 Apr 18. PMID: 35811094.

Nasillo V, Lagreca I, Vallerini D, Barozzi P, Riva G, Maccaferri M, Paolini A, Forghieri F, Fiorcari S, Maffei R, Martinelli S, Atene CG, Castelli I, Marasca R, Potenza L, Comoli P, Manfredini R, Tagliafico E, Trenti T, Luppi M. BTK Inhibitors Impair Platelet-Mediated Antifungal Activity. Cells. 2022 Mar 16;11(6):1003. doi: 10.3390/cells11061003. PMID: 35326454; PMCID: PMC8947638.

Genovese E, Mirabile M, Rontauroli S, Sartini S, Fantini S, Tavernari L, Maccaferri M, Guglielmelli P, Bianchi E, Parenti S, Carretta C, Mallia S, Castellano S, Colasante C, Balliu M, Bartalucci N, Palmieri R, Ottone T, Mora B, Potenza L, Passamonti F, Voso MT, Luppi M, Vannucchi AM, Tagliafico E, Manfredini R, On Behalf Of The Mynerva MYeloid NEoplasms Research Venture Airc. The Response to Oxidative Damage Correlates with Driver Mutations and Clinical Outcome in Patients with Myelofibrosis. Antioxidants (Basel). 2022 Jan 5;11(1):113. doi: 10.3390/antiox11010113. PMID: 35052617; PMCID: PMC8772737.


2021

Kueckelhaus M, Rothoeft T, De Rosa L, Yeni B, Ohmann T, Maier C, Eitner L, Metze D, Losi L, Secone Seconetti A, De Luca M, Hirsch T. Transgenic Epidermal Cultures for Junctional Epidermolysis Bullosa – 5-Year Outcomes. N Engl J Med. 2021 Dec 9;385(24):2264-2270. doi: 10.1056/NEJMoa2108544.PMID: 34881838

De Rosa L, Enzo E, Zardi G, Bodemer C, Magnoni C, Schneider H, De Luca M. Hologene 5: A Phase II/III Clinical Trial of Combined Cell and Gene Therapy of Junctional Epidermolysis Bullosa. Front Genet. 2021 Sep 1;12:705019. doi: 10.3389/fgene.2021.705019. eCollection 2021.

Enzo E, Secone Seconetti A, Forcato M, Tenedini E, Polito MP, Sala I, Carulli S, Contin R, Peano C, Tagliafico E, Bicciato S, Bondanza S, De Luca M. Single-keratinocyte transcriptomic analyses identify different clonal types and proliferative potential mediated by FOXM1 in human epidermal stem cells. Nat Commun. 2021 May 4;12(1):2505. doi: 10.1038/s41467-021-22779-9.

Maurizi E, Adamo D, Magrelli FA, Galaverni G, Attico E, Merra A, Maffezzoni MBR, Losi L, Genna VG, Sceberras V, Pellegrini G. Regenerative Medicine of Epithelia: Lessons From the Past and Future Goals. Front Bioeng Biotechnol . 2021 Mar 25;9:652214. doi: 10.3389/fbioe.2021.652214. eCollection 2021.

S. Rontauroli, S. Castellano, P. Guglielmelli, R. Zini, E. Bianchi, E. Genovese, C. Carretta, S. Parenti, S. Fantini, S. Mallia, L.Tavernari, S. Sartini, M. Mirabile, C. Mannarelli, F. Gesullo, A. Pacilli, D. Pietra, E. Rumi, S. Salmoiraghi, B. Mora, L. Villani, A. Grilli, V. Rosti, G. Barosi, F. Passamonti, A. Rambaldi, L. Malcovati, M. Cazzola, S. Bicciato, E. Tagliafico, A.M. Vannucchi and R. Manfredini, on behalf of Mynerva (MYeloid NEoplasms Research Venture AIRC) investigators. Gene expression profile correlates with molecular and clinical features in myelofibrosis patients. Blood Advances, Blood Adv. 2021 Mar 9;5(5):1452-1462. doi: 10.1182/bloodadvances.2020003614.

Castellano S, Cestari F, Faglioni G, Tenedini E, Marino M, Artuso L, Manfredini R, Luppi M, Trenti T, Tagliafico E. iVar, an Interpretation-Oriented Tool to Manage the Update and Revision of Variant Annotation and Classification. Genes (Basel). 2021 Mar 8;12(3):384. doi: 10.3390/genes12030384.

Wagner RN, Piñón Hofbauer J, Wally V, Kofler B, Schmuth M, De Rosa L, De Luca M, Bauer JW. Epigenetic and metabolic regulation of epidermal homeostasis, Exp Dermatol. 2021 Feb 18. doi: 10.1111/exd.14305. Online ahead of print.

Nasillo V, Riva G, Paolini A, Forghieri F, Roncati L, Lusenti B, Maccaferri, M, Messerotti A, Pioli V, Gilioli A, Bettelli F, Giusti D, Barozzi P, Lagreca I,Maffei R, Marasca R, Potenza L, Comoli P, Manfredini R, Maiorana A, Tagliafico E, Luppi M, Trenti T. Inflammatory Microenvironment and Specific T Cells in Myeloproliferative Neoplasms: Immunopathogenesis and Novel Immunotherapies. Int J Mol Sci. 2021 Feb 14;22(4):1906. doi: 10.3390/ijms22041906.

Patrizi C, Llado M, Benati D, Iodice C, Marrocco E, Guarascio R, Surace EM, Cheetam ME, Auricchio A, Recchia A. Allele-specific editing ameliorates dominant retinitis pigmentosa in a transgenic mouse model, Am J Hum Genet. 2021 Feb 4; 108(2): 295–308. doi: 10.1016/j.ajhg.2021.01.006

Parenti S, Rontauroli S, Carretta C, Mallia S, Genovese E, Chiereghin C, Peano C, Bianchi E, Fantini S, Sartini S, Tavernari L, Romano O, Bicciato S, Tagliafico E, Della Porta M and Manfredini R. Mutated clones driving leukemic transformation are already detectable at the single cell level in CD34-positive cells in the chronic phase of primary myelofibrosis. NPJ Precis Oncol. 2021 Feb 4;5(1):4. doi: 10.1038/s41698-021-00144-9.

Attico E, Galaverni G and Pellegrini G Clinical Studies of COMET for total LSCD: a review of the methods and molecular markers for follow up characterizations Curr Ophthalmol Rep 2021.

Parenti S, Rabacchi C, Marino M, Tenedini E, Artuso L, Castellano S, Carretta, C, Mallia S, Cortesi L, Toss A, Barbieri E, Manfredini R, Luppi M, Trenti T, Tagliafico E. Characterization of New ATM Deletion Associated with Hereditary Breast Cancer. Genes (Basel). 2021 Jan 21;12(2):136. doi: 10.3390/genes12020136.


2020

Carretta C, Mallia S, Genovese E, Parenti S, Rontauroli S, Bianchi E, Fantini S, Sartini S, Tavernari L, Tagliafico E, Manfredini R., “Genomic Analysis of Hematopoietic Stem Cell at the Single-Cell Level: Optimization of Cell Fixation and Whole Genome Amplification (WGA) Protocol”, Int J Mol Sci. 2020 Oct 6; 21 (19): E7366. doi: 10.3390/ijms21197366.

Maurizi E, Schiroli D, Zini R, Limongelli A, Mistò R, Macaluso C, Pellegrini G. A fine-tuned β-catenin regulation during proliferation of corneal endothelial cells revealed using proteomics analysis. Sci Rep. 2020 Aug 14;10(1):13841. doi: 10.1038/s41598-020-70800-w.

Zanfi ED, Fantini S, Lotti R, Bertesi M, Marconi A, Grande A, Manfredini R, Pincelli C, Zanocco-Marani T. Wnt/CTNNB1 Signal Transduction Pathway Inhibits the Expression of ZFP36 in Squamous Cell Carcinoma, by Inducing Transcriptional Repressors SNAI1, SLUG and TWIST. Int J Mol Sci2020 Aug 8;21(16):E5692. doi: 10.3390/ijms21165692.

Magrelli F M, Merra A, Pellegrini G. Surgery Versus ATMPs: An Example From Ophthalmology. Front Bioeng Biotechnol. 2020 Jun 10;8:440. doi: 10.3389/fbioe.2020.00440. eCollection 2020.

De Rosa L, Latella MC, Secone Seconetti A, Cattelani C, Bauer JW, Bondanza S, De Luca M. Toward Combined Cell and Gene Therapy for Genodermatoses. Cold Spring Harb Perspect Biol. 2020 May 1;12(5):a035667. doi: 10.1101/cshperspect.a035667. Epub 2019 Oct 25.


2019

Scherm MG, Serr I, Zahm AM, Schug J, Bellusci S, Manfredini R, Salb VK,Gerlach K, Weigmann B, Ziegler AG, Kaestner KH, Daniel C. miRNA142-3p targetsTet2 and impairs Treg differentiation and stability in models of type 1 diabetes. Nat Commun. 2019 Dec 13;10(1):5697. doi: 10.1038/s41467-019-13587-3.

Bassi R, Bucci EM, Calogero R, Carninci P, Ciliberto G, Conte P, De Luca M, Corbellini G, Giordano A, Marchionni L, Massaro Giordano G, Parini A, Sbardella G. Look for methods, not conclusions. Cell Death and Disease 2019 Dec 1;10:931 doi: 10.1038/s41419-019-2179-8

Deng SX, Borderie V, Chan CC, Dana R, Figueiredo FC, Gomes JAP, Pellegrini G, Shimmura S, Kruse FE. Reply. Cornea. 2019 Dec;38(12):e56-e57. doi: 10.1097/ICO.0000000000002145.

Vukasovic A, Asnaghi MA, Kostesic P, Quasnichka H, Cozzolino C, Pusic M, Hails L, Trainor N, Krause C, Figallo E, Filardo G, Kon E, Wixmerten A, Maticic D, Pellegrini G, Kafienah W, Hudetz D, Smith T, Martin I, Ivkovic A, Wendt D. Bioreactor-manufactured cartilage grafts repair acute and chronic osteochondral defects in large animal studies. Cell Prolif. 2019 Nov;52(6):e12653. doi: 10.1111/cpr.12653. Epub 2019 Sep 6. 

Barbalinardo M, Di Giosia M, Polishchuk I, Magnabosco G, Fermani S, Biscarini F, Calvaresi M, Zerbetto F, Pellegrini G, Falini G, Pokroy B, Valle F. Retinoic acid/calcite micro-carriers inserted in fibrin scaffolds modulate neuronal cell differentiation. J Mater Chem B. 2019 Oct 14;7(38):5808-5813. doi: 10.1039/c9tb01148j. Epub 2019 Sep 5.

Pellegrini G. New Drugs?. Pharmadvances 0:6-8, 2019 September doi: 10.36118/pharmadvances.00.2019.04

Salati S, Genovese E, Carretta C, Zini R, Bartalucci N, Prudente Z, Pennucci V, Ruberti S, Rossi C, Rontauroli S, Enzo E, Calabresi L, Balliu M, Mannarelli C, Bianchi E, Guglielmelli P, Tagliafico E, Vannucchi AM, Manfredini R. Calreticulin Ins5 and Del52 mutations impair unfolded protein and oxidative stress responses in K562 cells expressing CALR mutants.Sci Rep. 2019 Jul 22;9(1):10558. doi: 10.1038/s41598-019-46843-z.

Sceberras V, Attico E, Bianchi E, Galaverni G, Melonari M, Corradini F, Fantacci M, Ribbene A, Losi L, Balò S, Lazzeri M, Trombetta C, Rizzo M, Manfredini R, Barbagli G, Pellegrini G. Preclinical study for treatment of hypospadias by advanced therapy medicinal products.. World J Urol. 2019 Jul 9. doi: 10.1007/s00345-019-02864-x. [Epub ahead of print]

Chiavelli C., Attico E., Sceberras V., Fantacci M., Melonari M., Pellegrini G. Stem Cells and Ocular Regeneration – Chapter in Encyclopedia of Tissue Engineering and Regenerative Medicine. Elsevier. – ISBN: 9780128136997. 2019.

Rotunno G, Mannarelli C, Brogi G, Pacilli A, Gesullo F, Mannelli F, Fiaccabrino S, Sordi B, Paoli C, Marone I, Rumi E, Manfredini R, Barosi G, Cazzola M, Vannucchi AM, Guglielmelli P. Spectrum of ASXL1 mutations in primary myelofibrosis: prognostic impact of the ASXL1 p.G646Wfs*12 mutation. Blood 2019 Jun 27;133(26):2802-2808. doi: 10.1182/blood.2018879536. Epub 2019 May 10.

De Luca M, Aiuti A, Cossu G, Parmar M, Pellegrini G, Robey PG. Advances in stem cell research and therapeutic development. Nat Cell Biol. 2019 Jul;21(7):801-811. doi: 10.1038/s41556-019-0344-z. Epub 2019 Jun 17

De Rosa L, Secone Seconetti A, De Santis G, Pellacani G, Hirsch T, Rothoeft T, Teig N, Pellegrini G, Bauer JW, De Luca M. Laminin 332-Dependent YAP Dysregulation Depletes Epidermal Stem Cells in Junctional Epidermolysis Bullosa. Cell Rep. 2019 May 14;27(7):2036-2049.e6. doi: 10.1016/j.celrep.2019.04.055.

De Pace B, Fiorentini C, Ciardo S1 Chester J, Kaleci S, Veltri T, De Luca M, Pellacani G. Inherited epidermolysis bullosa: description of clinical and subclinical morphological features with optical coherence tomography. J Eur Acad Dermatol Venereol. 2019 Mar;33(3):e120-e123. doi: 10.1111/jdv.15304. Epub 2018 Nov 15.

Deng SX, Borderie V, Chan CC, Dana R, Figueiredo FC, Gomes JAP, Pellegrini G, Shimmura S, Kruse FE; and The International Limbal Stem Cell Deficiency Working Group. Global Consensus on Definition, Classification, Diagnosis, and Staging of Limbal Stem Cell Deficiency. Cornea. 2019 Mar;38(3):364-375. doi: 10.1097/ICO.0000000000001820.

Rossignoli F, Grisendi G, Spano C, Golinelli G, Recchia A, Rovesti G, Orsi G, Veronesi E, Horwitz EM, Dominici M. Inducible Caspase9-mediated suicide gene for MSC-based cancer gene therapy. Cancer Gene Ther. 2019 Feb;26(1-2):11-16. doi: 10.1038/s41417-018-0034-1. Epub 2018 Jun 29.

Recchia A. AAV-CRISPR Persistence in the Eye of the Beholder. Mol Ther. 2019 Jan 2;27(1):12-14. doi: 10.1016/j.ymthe.2018.12.007. Epub 2018 Dec 14.

Benati D, Marigo V, Recchia A. CRISPR/Cas9 Gene Editing In Vitro and in Retinal Cells In Vivo. Methods Mol Biol. 2019;1834:59-74. doi: 10.1007/978-1-4939-8669-9_4.


2018

Rossi C, Zini R, Rontauroli S, Ruberti S, Prudente Z, Barbieri G, Bianchi E, Salati S, Genovese E, Bartalucci N, Guglielmelli P, Tagliafico E, Rosti V, Barosi G, Vannucchi AM, Manfredini R; AGIMM (AIRC-Gruppo Italiano Malattie Mieloproliferative) investigators. Role of TGF-β1/miR-382-5p/SOD2 axis in the induction of oxidative stress in CD34+ cells from primary myelofibrosis. Mol Oncol. 2018 Dec;12(12):2102-2123. doi: 10.1002/1878-0261.12387. Epub 2018 Nov 16.

Pellegrini G, De Luca M. Living with Keratinocytes. Stem Cell Reports. 2018 Nov 13;11(5):1026-1033. doi: 10.1016/j.stemcr.2018.10.005.

Sugarman J, Barker RA, Kerridge I, Lysaght T, Pellegrini G, Sipp D, Tanner C. Tackling Ethical Challenges of Premature Delivery of Stem Cell-Based Therapies: ISSCR 2018 Annual Meeting Focus Session Report. Stem Cell Reports. 2018 Nov 13;11(5):1021-1025. doi: 10.1016/j.stemcr.2018.10.020.

Chorzalska A, Morgan J, Ahsan N, Treaba DO, Olszewski AJ, Petersen M, Kingston N, Cheng Y, Lombardo K, Schorl C, Yu X, Zini R, Pacilli A, Tepper A, Coburn J, Hryniewicz-Jankowska A, Zhao TC, Oancea E, Reagan JL, Liang O, Kotula L, Quesenberry PJ, Gruppuso PA, Manfredini R, Vannucchi AM, Dubielecka PM. Bone marrow-specific loss of ABI1 induces myeloproliferative neoplasm with features resembling human myelofibrosis. Blood. 2018 Nov 8;132(19):2053-2066. doi: 10.1182/blood-2018-05-848408. Epub 2018 Sep 13.

Benati D, Miselli F, Cocchiarella F, Patrizi C, Carretero M, Baldassarri S, Ammendola V, Has C, Colloca S, Del Rio M, Larcher F, Recchia A. CRISPR/Cas9-Mediated In Situ Correction of LAMB3 Gene in Keratinocytes Derived from a Junctional Epidermolysis Bullosa Patient. Mol Ther. 2018 Nov 7;26(11):2592-2603. doi: 10.1016/j.ymthe.2018.07.024. Epub 2018 Aug 4.

Attico E, Sceberras V, Pellegrini G. Approaches for Effective Clinical Application of Stem Cell Transplantation. Current Transplantation 2018;5(3):244-250. doi: 10.1007/s40472-018-0202-0. Epub 2018 Aug 2

Lincoln V, Cogan J, Hou Y, Hirsch M, Hao M, Alexeev V, De Luca M, De Rosa L, Bauer JW, Woodley DT, Chen M. Gentamicin induces LAMB3 nonsense mutation readthrough and restores functional laminin 332 in junctional epidermolysis bullosa. Proc Natl Acad Sci U S A. 2018 2018 Jul 10;115(28):E6536-E6545. doi: 10.1073/pnas.1803154115. Epub 2018 Jun 26

Stern JH, Tian Y, Funderburgh J, Pellegrini G, Zhang K, Goldberg JL, Ali RR, Young M, Xie Y, Temple S. Regenerating Eye Tissues to Preserve and Restore Vision. Cell Stem Cell. 2018 Jun 1;22(6):834-849. doi: 10.1016/j.stem.2018.05.013

Ricciardi MR, Salvestrini V, Licchetta R, Mirabilii S, Forcato M, Gugliotta G, Salati S, Castagnetti F, Rosti G, Breccia M, Alimena G, Manfredini R, Bicciato S, Lemoli RM, Tafuri A. Differential proteomic profile of leukemic CD34+ progenitor cells from chronic myeloid leukemia patients. Oncotarget. 2018 Apr 24;9(31):21758-21769. doi: 10.18632/oncotarget.24938. eCollection 2018 Apr 24.

Horenstein AL, Chillemi A, Zini R, Quarona V, Bianchi N, Manfredini R, Gambari R, Malavasi F, Ferrari D. Cytokine-Induced Killer Cells Express CD39, CD38, CD203a, CD73 Ectoenzymes and P1 Adenosinergic Receptors. Front Pharmacol. 2018 Apr 20;9:196. doi: 10.3389/fphar.2018.00196. eCollection 2018.

De Rosa L, Koller U, Bauer JW, De Luca M, Reichelt J. Advances on potential therapeutic options for epidermolysis bullosa. Expert Opinion on Orphan Drugs 2018 Apr 17;, vol. 6, p. 283-293, ISSN: 2167-8707, doi: 10.1080/21678707.2018.1463216

Cortesi F, Delfanti G, Grilli A, Calcinotto A, Gorini F, Pucci F, Lucianò R, Grioni M, Recchia A, Benigni F, Briganti A, Salonia A, De Palma M, Bicciato S, Doglioni C, Bellone M, Casorati G, Dellabona P. Bimodal CD40/Fas-Dependent Crosstalk between iNKT Cells and Tumor-Associated Macrophages Impairs Prostate Cancer Progression. Cell Rep. 2018 Mar 13;22(11):3006-3020. doi: 10.1016/j.celrep.2018.02.058.

Ruberti S, Bianchi E, Guglielmelli P, Rontauroli S, Barbieri G, Tavernari L, Fanelli T, Norfo R, Pennucci V, Fattori GC, Mannarelli C, Bartalucci N, Mora B, Elli L, Avanzini MA, Rossi C, Salmoiraghi S, Zini R, Salati S, Prudente Z, Rosti V, Passamonti F, Rambaldi A, Ferrari S, Tagliafico E, Vannucchi AM, Manfredini R. Involvement of MAF/SPP1 axis in the development of bone marrow fibrosis in PMF patients. Leukemia. 2018 Feb;32(2):438-449. doi: 10.1038/leu.2017.220. Epub 2017 Jul 12.

Benati D, Cocchiarella F, Recchia A. An Efficient In Vitro Transposition Method by a Transcriptionally Regulated Sleeping Beauty System Packaged into an Integration Defective Lentiviral Vector. J. Vis. Exp.(131), 2018 Jan 12;(131), doi:10.3791/56742

Pellegrini G, Ardigò D, Milazzo G, Iotti G, Guatelli P, Pelosi D, De Luca M. Navigating Market Authorization: The Path Holoclar Took to Become the First Stem Cell Product Approved in the European Union. Stem Cells Transl Med. 2018 Jan;7(1):146-154. doi: 10.1002/sctm.17-0003. Epub 2017 Dec 27


2017

Salati S, Prudente Z, Genovese E, Pennucci V, Rontauroli S, Bartalucci N, Mannarelli C, Ruberti S, Zini R, Rossi C, Bianchi E, Guglielmelli P, Tagliafico E, Vannucchi AM, Manfredini R. Calreticulin affects hematopoietic stem/progenitor cell fate by impacting erythroid and megakaryocytic differentiation. Stem Cells Dev. 2017 Dec 19. doi: 10.1089/scd.2017.0137. [Epub ahead of print]

Zini R, Guglielmelli P, Pietra D, Rumi E, Rossi C, Rontauroli S, Genovese E, Fanelli T, Calabresi L, Bianchi E, Salati S, Cazzola M, Tagliafico E, Vannucchi AM, Manfredini R; AGIMM (AIRC Gruppo Italiano Malattie Mieloproliferative) investigators. CALR mutational status identifies different disease subtypes of essential thrombocythemia showing distinct expression profiles. Blood Cancer J. 2017 Dec 8;7(12):638. doi: 10.1038/s41408-017-0010-2.

Catani L, Sollazzo D, Bianchi E, Ciciarello M, Antoniani C, Foscoli L, Caraceni P, Giannone FA, Baldassarre M, Giordano R, Montemurro T, Montelatici E, D’Errico A, Andreone P, Giudice V, Curti A, Manfredini R, Lemoli RM. Molecular and functional characterization of CD133+ stem/progenitor cells infused in patients with end-stage liver disease reveals their interplay with stromal liver cells. Cytotherapy. 2017 Dec;19(12):1447-1461. doi: 10.1016/j.jcyt.2017.08.001. Epub 2017 Sep 14.

Hirsch T, Rothoeft T, Teig N, Bauer JW, Pellegrini G, De Rosa L, Scaglione D, Reichelt J, Klausegger A, Kneisz D, Romano O, Secone Seconetti A, Contin R, Enzo E, Jurman I, Carulli S, Jacobsen F, Luecke T, Lehnhardt M, Fischer M, Kueckelhaus M, Quaglino D, Morgante M, Bicciato S, Bondanza S, De Luca M. Regeneration of the entire human epidermis using transgenic stem cells. Nature. 2017 Nov 16;551(7680):327-332. doi: 10.1038/nature24487. Epub 2017 Nov 8.

Mesiano G, Zini R, Montagner G, Bianchi N, Manfredini R, Chillemi A, Aglietta M, Grignani G, Lampronti I, Fiorino E, Malavasi F, Sangiolo D, Gambari R, Ferrari D. Analytic and Dynamic Secretory Profile of Patient-Derived Cytokine-Induced Killer Cells. Mol Med. 2017 Oct;23:235-246. doi: 10.2119/molmed.2017.00084. Epub 2017 Aug 9.

Salati S, Salvestrini V, Carretta C, Genovese E, Rontauroli S, Zini R, Rossi C, Ruberti S, Bianchi E, Barbieri G, Curti A, Castagnetti F, Gugliotta G, Rosti G, Bergamaschi M, Tafuri A, Tagliafico E, Lemoli R, Manfredini R. Deregulated expression of miR-29a-3p, miR-494-3p and miR-660-5p affects sensitivity to tyrosine kinase inhibitors in CML leukemic stem cells. Oncotarget. 2017 Jul 25;8(30):49451-49469. doi: 10.18632/oncotarget.17706.

Sipp D, Caulfield T, Kaye J, Barfoot J, Blackburn C, Chan S, De Luca M, Kent A, McCabe C, Munsie M, Sleeboom-Faulkner M, Sugarman J, van Zimmeren E, Zarzeczny A, Rasko JEJ. Marketing of unproven stem cell-based interventions: A call to action. Sci Transl Med. 2017 Jul 5;9(397). pii: eaag0426. doi: 10.1126/scitranslmed.aag0426

Rama P, Ferrari G, Pellegrini G. Cultivated limbal epithelial transplantation. Curr Opin Ophthalmol. 2017 Jul;28(4):387-389. doi: 10.1097/ICU.0000000000000382

Latella MC, Cocchiarella F, De Rosa L, Turchiano G, Gonçalves MA, Larcher F, De Luca M, Recchia A. Correction of recessive dystrophic epidermolysis bullosa by transposon-mediated integration of COL7A1 in transplantable patient-derived primary keratinocytes. J Invest Dermatol. 2017 Apr; 137(4):836-44. Epub 2016 Dec 24

Rontauroli S, Norfo R, Pennucci V, Zini R, Ruberti S, Bianchi E, Salati S, Prudente Z, Rossi C, Rosti V, Guglielmelli P, Barosi G, Vannucchi A, Tagliafico E, Manfredini R. miR-494-3p overexpression promotes megakaryocytopoiesis in primary myelofibrosis hematopoietic stem/progenitor cells by targeting SOCS6. Oncotarget. 2017 Mar 28;8(13):21380-21397. doi: 10.18632/oncotarget.15226.

Bianchi E, Ruberti S, Rontauroli S, Guglielmelli P, Salati S, Rossi C, Zini R, Tagliafico E, Vannucchi AM, Manfredini R. Role of miR-34a-5p in Hematopoietic Progenitor Cells Proliferation and Fate Decision: Novel Insights into the Pathogenesis of Primary Myelofibrosis. Int J Mol Sci. 2017 Jan 13;18(1). pii: E145. doi: 10.3390/ijms18010145.

Bauer JW, Koller J, Murauer EM, De Rosa L, Enzo E, Carulli S, Bondanza S, Recchia A, Muss W, Diem A, Mayr E, Schlager P, Gratz IK, Pellegrini G, De Luca M. Closure of a large chronic wound through transplantation of gene-corrected epidermal stem cells. J Invest Dermatol. 2017 Mar;137(3):778-781. doi: 10.1016/j.jid.2016.10.038. Epub 2016 Nov 10


2016

Barbagli G, Pellegrini G, Corradini F, Montorsi F, Sansalone S, Butnaru D, Lazzeri M. One-stage Penile Urethroplasty Using Oral Mucosal Graft and Glue. Eur Urol. 2016 Dec;70(6):1069-1075. doi: 10.1016/j.eururo.2016.04.025. Epub 2016 May 6

Bernardis I, Chiesi L, Tenedini E, Artuso L, Percesepe A, Artusi V, Simone ML, Manfredini R, Camparini M, Rinaldi C, Ciardella A, Graziano C, Balducci N, Tranchina A, Cavallini GM, Pietrangelo A, Marigo V, Tagliafico E. Unravelling the Complexity of Inherited Retinal Dystrophies Molecular Testing: Added Value of Targeted Next-Generation Sequencing. Biomed Res Int 2016; 2016: 6341870. doi: 10.1155/2016/6341870. Epub 2016 Dec 29

Latella MC, Di Salvo MT, Cocchiarella F, Benati D, Grisendi G, Comitato A, Marigo V, Recchia A. In vivo Editing of the Human Mutant Rhodopsin Gene by Electroporation of Plasmid-based CRISPR/Cas9 in the Mouse Retina.Mol Ther Nucleic Acids. 2016 Nov 22;5(11):e389. doi: 10.1038/mtna.2016.92. 

Zini R, Rossi C, Norfo R, Pennucci V, Barbieri G, Ruberti S, Rontauroli S, Salati S, Bianchi E, Manfredini R. miR-382-5p Controls Hematopoietic Stem Cell Differentiation Through the Downregulation of MXD1. Stem Cells Dev 2016 Oct; 25: 1433-43. doi: 10.1089/scd.2016.0150. Epub 2016 Sep 7

Rotunno G, Pacilli A, Artusi V, Rumi E, Maffioli M, Delaini F, Brogi G, Fanelli T, Pancrazzi A, Pietra D, Bernardis I, Belotti C, Pieri L, Sant’Antonio E, Salmoiraghi S, Cilloni D, Rambaldi A, Passamonti F, Barbui T, Manfredini R, Cazzola M, Tagliafico E, Vannucchi AM, Guglielmelli P. Epidemiology and clinical relevance of mutations in post-polycythemia vera and post-essential thrombocythemia myelofibrosis. A study on 359 patients of the AGIMM group. Am J Hematol. 2016 Jul;91(7):681-6. doi: 10.1002/ajh.24377. Epub 2016 May 11

Tomasella A, Picco R, Ciotti S, Sgorbissa A, Bianchi E, Manfredini R, Benedetti F, Trimarco V, Frezzato F, Trentin L, Semenzato G, Delia D, Brancolini C. The isopeptidase inhibitor 2cPE triggers proteotoxic stress and ATM activation in chronic lymphocytic leukemia cells. Oncotarget. 2016 Jul 19;7(29):45429-45443. doi: 10.18632/oncotarget.9742.

Milazzo G, Ardigò D, Toschi M, Matuska S, Rama P, De Luca M, Pellegrini G. Holoclar: first of its kind in more ways than one. Cell Gene Therapy Insights 2016 July 6;2(2):183-197. doi:10.18609/cgti.2016.023

Calura E, Pizzini S, Bisognin A, Sales G, Coppe A, Gaffo E, Fanelli T, Mannarelli C, Zini R, Norfo R, Pennucci V, Manfredini R, Romualdi C, Guglielmelli P, Vannucchi AM and Bortoluzzi S. A data-driven network model of primary myelofibrosis: transcriptional and post-transcriptional alterations in CD34+ cells. Blood Cancer J. 2016 Jun 24;6(6):e439. doi: 10.1038/bcj.2016.47

Cocchiarella F, Latella MC, Basile V, Miselli F, Galla M, Imbriano C, Recchia A. Transcriptionally regulated and nontoxic delivery of the hyperactive Sleeping Beauty Transposase. Mol Ther Methods Clin Dev. 2016 Jun 15;3:16038. doi: 10.1038/mtm.2016.38. eCollection 2016.

Cossu G, Buccione R, De Luca M. A discussion on cell therapy in Manchester. Stem Cell Res. 2016 May;16(3):614-6. doi: 10.1016/j.scr.2016.03.005. Epub 2016 Mar 21.

Pellegrini G, Lambiase A, Macaluso C, Pocobelli A, Deng S, Cavallini GM, Esteki R, Rama P, From discovery to approval of an advanced therapy medicinal product-containing stem cells, in the EU. Regen Med. 2016 Jun;11(4):407-20. doi: 10.2217/rme-2015-0051. Epub 2016 Apr 19.

Salati S, Zini R, Nuzzo S, Guglielmelli P, Pennucci V, Prudente Z, Ruberti S, Rontauroli S, Norfo R, Bianchi E, Bogani C, Rotunno G, Fanelli T, Mannarelli C, Rosti V, Salmoiraghi S, Pietra D, Ferrari S, Barosi G, Rambaldi A, Cazzola M, Bicciato S, Tagliafico E, Vannucchi AM, Manfredini R; AGIMM (AIRC Gruppo Italiano Malattie Mieloproliferative) investigators. Integrative analysis of copy number and gene expression data suggests novel pathogenetic mechanisms in Primary Myelofibrosis. Int J Cancer. 2016 Apr 1;138(7):1657-69. doi: 10.1002/ijc.29920. Epub 2015 Nov 25

Bianchi E, Norfo R, Pennucci V, Zini R, Manfredini R. Genomic landscape of megakaryocytopoiesis and platelet function defects. Blood. 2016 Mar 10;127(10):1249-59. doi: 10.1182/blood-2015-07-607952. Epub 2016 Jan 19

Corradini F, Zattoni M, Barbagli G, Bianchi G, Giovanardi M, Serafini C, Genna V, Ribbene A, Balò S, Fidanza F, Lazzeri M, De Luca M, Pellegrini G. Comparative Assessment Of Cultures From Oral And Urethral Stem Cells For Urethral Regeneration. Curr Stem Cell Res Ther. 2016; 11(8):643-65. doi: 10.2174/1574888X10666150902094644 Epub 2015 Sep 1


2015

Murauer EM, Koller U, Pellegrini G, De Luca M, Bauer JW, Advances in Gene/Cell Therapy in Epidermolysis Bullosa, Keio J Med. 2015 Jun 25;64(2):21-5. doi: 10.2302/kjm.2014-0013-RE. Epub 2015 Jun 6

Marini B, Kertesz-Farkas A, Ali H, Lucic B, Lisek K, Manganaro L, Pongor S, Luzzati R, Recchia A, Mavilio F, Giacca M, Lusic M. Nuclear architecture dictates HIV-1 integration site selection. Nature. 2015 May 14;521(7551):227-31. doi: 10.1038/nature14226. Epub 2015 Mar 2.

Tenedini E, Artuso L, Bernardis I, Artusi V, Percesepe A, De Rosa L, Contin R, Manfredini R, Pellecani G, Giannetti A, Pagani J, De Luca M, Tagliafico E. Amplicon-based NGS: an effective approach for the molecular diagnosis of Epidermolysis Bullosa. Br J Dermatol. 2015  Sep;173(3):731-8. doi: 10.1111/bjd.13858. Epub 2015 Jul 29.

Bianchi E, Bulgarelli J, Ruberti S, Rontauroli S, Sacchi G, Norfo R, Pennucci V, Zini R, Salati S, Prudente Z, Ferrari S, Manfredini R, MYB controls erythroid versus megakaryocyte lineage fate decision through the miR-486-3p-mediated down-regulation of MAF. Cell Death Differ, 2015 Dec;22(12):1906-21. doi: 10.1038/cdd.2015.30. Epub 2015 Apr 10

Droz-Georget Lathion S, Rochat A, Knott G, Recchia A, Martinet D, Benmohammed S, Grasset N, Zaffalon A, Besuchet Schmutz N, Savioz-Dayer E, Beckmann JS, Rougemont J, Mavilio F, Barrandon Y. A single epidermal stem cell strategy for safe ex vivo gene therapy. EMBO Mol Med. 2015 Feb 27;7(4):380-93. doi: 10.15252/emmm.201404353

Pennucci V, Zini R, Norfo R, Guglielmelli P, Bianchi E, Salati S, Sacchi G, Prudente Z, Tenedini E, Ruberti S, Paoli C, Fanelli T, Mannarelli C, Tagliafico E, Ferrari S, Vannucchi AM,  Manfredini R. Abnormal expression patterns of WT1-as, MEG3 and ANRIL long non-coding RNAs in CD34+ cells from patients with primary myelofibrosis and their clinical correlations. Leuk Lymphoma. 2015 Feb;56(2):492-6. doi: 10.3109/10428194.2014.910661. Epub 2014 Jun 16.


2014

Ianiro A, Giosia MD, Fermani S, Samorì C, Barbalinardo M, Valle F, Pellegrini G, Biscarini F, Zerbetto F, Calvaresi M, Falini G. Customizing properties of β-chitin in squid pen (gladius) by chemical treatments. Mar Drugs. 2014 Dec 15;12(12):5979-92. doi: 10.3390/md12125979.

Turchiano G, Latella MC, Gogol-Döring A, Cattoglio C, Mavilio F, Izsvák Z, Ivics Z, Recchia A. Genomic analysis of Sleeping Beauty transposon integration in human somatic cells. PLoS One. 2014 Nov 12;9(11):e112712. doi: 10.1371/journal.pone.0112712. eCollection 2014.

Duarte B, Miselli F, Murillas R, Espinosa-Hevia L, Cigudosa JC, Recchia A, Del Río M, Larcher F. Long-term skin regeneration from a gene-targeted human epidermal stem cell clone. Mol. Ther. 2014 Nov;22(11):1878-80. doi: 10.1038/mt.2014.187.

Norfo R, Zini R, Pennucci V, Bianchi E, Salati S, Guglielmelli P, Bogani C, Fanelli T, Mannarelli C, Rosti V, Pietra D, Salmoiraghi S, Bisognin A, Ruberti S, Rontauroli S, Sacchi G, Prudente Z, Barosi G, Cazzola M, Rambaldi A, Bortoluzzi S, Ferrari S, Tagliafico E, Vannucchi AM, Manfredini R. miRNA-mRNA integrative analysis in primary myelofibrosis CD34+ cells unveils the role of miR-155/JARID2 axis in abnormal megakaryopoiesis. Blood. 2014 Sep 25;124(13):e21-32. doi: 10.1182/blood-2013-12-544197. Epub 2014 Aug 5.

Vannucchi AM, Rotunno G, Bartalucci N, Raugei G, Carrai V, Balliu M, Mannarelli C, Pacilli A, Calabresi L, Fjerza R, Pieri L, Bosi A, Manfredini R, Guglielmelli P. Calreticulin mutation-specific immunostaining in myeloproliferative neoplasms: pathogenetic insight and diagnostic value. Leukemia. 2014 2014 Sep;28(9):1811-8. doi: 10.1038/leu.2014.100. Epub 2014 Mar 12.

Guglielmelli P, Lasho TL, Rotunno G, Score J, Mannarelli C, Pancrazzi A, Biamonte F, Pardanani A, Zoi K, Reiter A, Duncombe A, Fanelli T, Pietra D, Rumi E, Finke C, Gangat N, Ketterling RP, Knudson RA, Hanson CA, Bosi A, Pereira A, Manfredini R, Cervantes F, Barosi G, Cazzola M, Cross NC, Vannucchi AM, Tefferi A. The number of prognostically detrimental mutations and prognosis in primary myelofibrosis: an international study of 797 patients. Leukemia. 2014 Sep;28(9):1804-10. doi: 10.1038/leu.2014.76. Epub 2014 Feb 19.

Cavallini GM, Pellegrini G, Volante V, Ducange P, De Maria M, Torlai G, Benatti C, Forlini M, Chemical injury treated with autologous limbal epithelial stem cell transplantation and subconjunctival bevacizumab, Clinical Ophthalmology, 2014 August 30;8:1671–1673 doi: 10.2147/OPTH.S65298. eCollection 2014.

Pellegrini G, De Luca M, Eyes on the prize: limbal stem cells and corneal restoration, Cell Stem Cell. 2014 Aug 7;15(2):121-2. doi: 10.1016/j.stem.2014.07.011.

Courtney DG, Atkinson SD, Allen EH, Moore JE, Walsh CP, Leslie Pedrioli DM, Macewen CJ, Pellegrini G, Maurizi E, Serafini C, Fantacci M, Liao H, Irvine AD, McLean WH, Moore TC. siRNA Silencing of the Mutant Keratin 12 Allele in Corneal Limbal Epithelial Cells Grown from Patients with Meesmann’s Epithelial Corneal Dystrophy. Invest Ophthalmol Vis Sci. 2014 May 6;55(5):3352-60. doi: 10.1167/iovs.13-12957.

Tenedini E, Bernardis I, Artusi V, Artuso L, Roncaglia E, Guglielmelli P, Pieri L, Bogani C, Biamonte F, Rotunno G, Mannarelli C, Bianchi E, Pancrazzi A, Fanelli T, Malagoli Tagliazucchi G, Ferrari S, Manfredini R, Vannucchi AM, Tagliafico E. Targeted cancer exome sequencing reveals recurrent mutations in myeloproliferative neoplasms, Leukemia. 2014 May;28(5):1052-9. doi: 10.1038/leu.2013.302. Epub 2013 Oct 22.

Guglielmelli P, Biamonte F,  Rotunno G, Artusi V, Artuso L,  Bernardis I, Tenedini E, Pieri L, Paoli C, Mannarelli C, Fjerza R, Rumi E, Stalbovskaya V, Squires M, Cazzola M, Manfredini R, Harrison C, Tagliafico E, Vannucchi AM.  Impact of mutational status on outcomes in myelofibrosis patients treated with ruxolitinib in the COMFORT-II study.  Blood. 2014 Apr 3;123(14):2157-60. doi: 10.1182/blood-2013-11-536557. Epub 2014 Jan 23.

Bianco P, Cattaneo E, De Luca M, Pani L. Stamina therapies: Let the record stand. Nature. 2014 Feb 27;506(7489):434. doi: 10.1038/506434c.

Courtney DG, Atkinson SD, Moore JE, Maurizi E, Serafini C, Pellegrini G, Black GC, Manson F, Yam GH, Allen EH, McLean WH, Moore TC. Development of allele specific gene silencing siRNAs for TGFBI Arg124Cys in Lattice Corneal Dystrophy Type I. Invest Ophthalmol Vis Sci. 2014 Feb 18;55(2):977-85. doi: 10.1167/iovs.13-13279

Pellegrini G, Rama P, Di Rocco A, Panaras A, De Luca M. Concise review: hurdles in a successful example of limbal stem cell-based regenerative medicine. Stem Cells. 2014 Jan;32(1):26-34. doi: 10.1002/stem.1517.

De Rosa L, Carulli S,  Cocchiarella F, Quaglino D, Enzo E, Franchini E, Giannetti A, De Santis G, Recchia A, Pellegrini G, De Luca M. Long-term stability and safety of transgenic cultured epidermal stem cells in gene therapy of junctional epidermolysis bullosa. Stem Cell Reports. 2014 Jan 14;2(1):1-8. doi: 10.1016/j.stemcr.2013.11.001. eCollection 2014.


2013

Coluccio A, Miselli F, Lombardo A, Marconi A, Malagoli Tagliazucchi G, Gonçalves MA, Pincelli C, Maruggi G, Del Rio M, Naldini L, Larcher F, Mavilio F, Recchia A. Targeted gene addition in human epithelial stem cells by zinc-finger nuclease-mediated homologous recombination. Mol Ther. 2013 Sep;21(9):1695-704. doi: 10.1038/mt.2013.143. Epub 2013 Jun 13.

Pellegrini G, Rama P, Matuska S, Lambiase A, Bonini B, Pocobelli A, Gisoldi Colabelli R, Spadea L, Fasciani R, Ballestrazzi E, Vinciguerra P, Rosetta P, Tortori A, Nardi M, Gabbriellini G, Traverso CE., Macaluso C, Losi L, Percesepe A, Venturi B, Corradini F, Panaras A, Di Rocco A, Guatelli P, De Luca M. Biological parameters determining the clinical outcome of cultured limbal stem cells. Regen Med. 2013 Sep;8(5):553-67. doi: 10.2217/rme.13.43. Epub 2013 Jun 3.

Vannucchi AM, Lasho TL, Guglielmelli P, Biamonte F, Pardanani A, Pereira A, Finke C, Score J, Gangat N, Mannarelli C, Ketterling RP, Rotunno G, Knudson RA, Susini MC, Laborde RR, Spolverini A, Pancrazzi A, Pieri L, Manfredini R, Tagliafico E, Zini R, Jones A, Zoi K, Reiter A, Duncombe A, Pietra D, Rumi E, Cervantes F, Barosi G, Cazzola M, Cross NC, Tefferi A. Mutations and prognosis in primary myelofibrosis. Leukemia. 2013 Sep;27(9):1861-9. doi: 10.1038/leu.2013.119. Epub 2013 Apr 26.

André-Schmutz I, Dal-Cortivo L, Six E, Kaltenbach S, Cocchiarella F, Le Chenadec J, Cagnard N, Cordier AG, Benachi A, Mandelbrot L, Azria E, Bouallag N, Luce S, Ternaux B, Reimann C, Revy P, Radford-Weiss I, Leschi C, Recchia A, Mavilio F, Cavazzana M, Blanche S. Genotoxic signature in cord blood cells of newborns exposed in utero to a Zidovudine-based antiretroviral combination. J Infect Dis. 2013 Jul 15;208(2):235-43. doi: 10.1093/infdis/jit149. Epub 2013 Apr 4.

Carulli S, Contin R, De Rosa L, Pellegrini G, De Luca M. The long and winding road that leads to a cure for epidermolysis bullosa. Regen Med. 2013 Jul;8(4):467-81. doi: 10.2217/rme.13.33.

Bianco P, Barker R, Brüstle O, Cattaneo E, Clevers H, Daley GQ, De Luca M, Goldstein L, Lindvall O, Mummery C, Robey PG, Sattler de Sousa E Brito C, Smith A. Regulation of stem cell therapies under attack in Europe: for whom the bell tolls. EMBO J. 2013 May 29;32(11):1489-95. doi: 10.1038/emboj.2013.114. Epub 2013 May 3.

Ciciarello M, Zini R, Rossi L, Salvestrini V, Ferrari D, Manfredini R, Lemoli RM. Extracellular purines promote the differentiation of human bone marrow-derived mesenchymal stem cells to the osteogenic and adipogenic lineages. Stem Cells Dev. 2013 Apr 1;22(7):1097-111. doi: 10.1089/scd.2012.0432. Epub 2012 Dec 21.

Holkers M, Maggio I, Liu J, Janssen JM, Miselli F, Mussolino C, Recchia A, Cathomen T, Gonçalves MA. Differential integrity of TALE nuclease genes following adenoviral and lentiviral vector gene transfer into human cells. Nucleic Acids Res. 2013 Mar 1;41(5):e63. doi: 10.1093/nar/gks1446. Epub 2012 Dec 28.

Cieri N, Camisa B, Cocchiarella F, Forcato M, Oliveira  G, Provasi E, Bondanza A, Bordignon C, Peccatori J, Ciceri F, Lupo-Stanghellini MT, Mavilio F, Mondino A, Bicciato S, Recchia A, Bonini C. IL-7 and IL-15 instruct the generation of human memory stem T cells from naïve precursors. Blood. 2013 Jan 24;121(4):573-84. doi: 10.1182/blood-2012-05-431718. Epub 2012 Nov 15.

Salati S, Lisignoli G, Manferdini C, Pennucci V, Zini R, Bianchi E, Norfo R, Facchini A, Ferrari S, Manfredini R. Co-culture of hematopoietic stem/progenitor cells with human osteblasts favours mono/macrophage differentiation at the expense of the erythroid lineage. PLoS One. 2013;8(1):e53496. doi: 10.1371/journal.pone.0053496. Epub 2013 Jan 22.


2012

Zini R, Norfo R, Ferrari F, Bianchi E, Salati S, Pennucci V, Sacchi G, Carboni C, Ceccherelli GB, Tagliafico E, Ferrari S, Manfredini R. Valproic acid triggers erythro/megakaryocyte lineage decision through induction of GFI1B and MLLT3 expression. Exp Hematol. 2012 Dec;40(12):1043-1054.e6. doi: 10.1016/j.exphem.2012.08.003. Epub 2012 Aug 10.

De Rosa L, De Luca M. Cell biology: Dormant and restless skin stem cells. Nature. 2012 Sep 13;489(7415):215-7. doi: 10.1038/489215a.

Bortoluzzi S, Bisognin A, Biasolo M, Guglielmelli P, Biamonte F, Norfo R, Manfredini R, Vannucchi AM. Characterization and discovery of novel miRNAs and moRNAs in JAK2V617F-mutated SET2 cells. Blood. 2012 Mar 29;119(13):e120-30. doi: 10.1182/blood-2011-07-368001. Epub 2012 Jan 5.

Salvestrini V, Zini R, Rossi L, Gulinelli S, Manfredini R, Bianchi E, Piacibello W, Caione L, Migliardi G, Ricciardi MR, Tafuri A, Romano M, Salati S, Di Virgilio F, Ferrari S, Baccarani M., Ferrari D, Lemoli RM. Purinergic signaling inhibits human acute myeloblastic leukemia cell proliferation, migration and engraftment in immunodeficient mouse, Blood. 2012 Jan 5;119(1):217-26. doi: 10.1182/blood-2011-07-370775. Epub 2011 Nov 3.

Corradini F, Venturi B, Pellegrini G, De Luca M. Methods for characterization/manipulation of human corneal stem cells and their applications in regenerative medicine. Methods Mol Biol. 2012;916:357-72. doi: 10.1007/978-1-61779-980-8_26.


2011

Recchia A, Mavilio F. Site-specific integration by the adeno-associated virus rep protein. Curr Gene Ther. 2011 Oct;11(5):399-405.

Ferrari D, Gulinelli S, Salvestrini V, Lucchetti G, Zini R, Manfredini R, Caione L, Piacibello W, Ciciarello M, Rossi L, Idzko M, Ferrari S, Di Virgilio F, Lemoli RM. Purinergic stimulation of human mesenchymal stem cells potentiates their chemotactic response to CXCL12 and increases the homing capacity and production of proinflammatory cytokines. Exp Hematol. 2011 Mar;39(3):360-74, 374.e1-5. doi: 10.1016/j.exphem.2010.12.001. Epub 2010 Dec 9.

Pellegrini G, Rama P, De Luca M. Vision from the right stem. Trends Mol Med. 2011 Jan;17(1):1-7 Epub 2010 Nov 11

Saghizadeh M, Soleymani S, Harounian A, Bhakta B, Troyanovsky SM, Brunken WJ, Pellegrini G, Ljubimov AV . Alterations of epithelial stem cell marker patterns in human diabetic corneas and effects of c-met gene therapy. Mol Vis. 2011;17:2177-90. Epub 2011 Aug 12.


2010

Cattoglio C, Maruggi G, Bartholomae C, Malani N, Pellin D, Cocchiarella F, Magnani Z, Ciceri F, Ambrosi A, von Kalle C, Bushman FD, Bonini C, Schmidt M, Mavilio F, Recchia A. High-definition mapping of retroviral integration sites defines the fate of allogeneic T cells after donor lymphocyte infusion. PLoS One. 2010 Dec 22;5(12):e15688. doi: 10.1371/journal.pone.0015688.

Bianchi E, Zini R, Salati S, Tenedini E, Norfo R, Tagliafico E, Manfredini R, Ferrari S. c-myb supports erythropoiesis through the transactivation of KLF1 and LMO2 expression. Blood. 2010 Nov 25;116(22):e99-110. doi: 10.1182/blood-2009-08-238311. Epub 2010 Aug 4.

Builles N, Janin-Manificat H, Malbouyres M, Justin V, Rovère MR, Pellegrini G, Torbet J, Hulmes DJ, Burillon C, Damour O, Ruggiero F. Use of magnetically oriented orthogonal collagen scaffolds for hemi-corneal reconstruction and regeneration. Biomaterials. 2010 Nov;31(32):8313-22. doi: 10.1016/j.biomaterials.2010.07.066. Epub 2010 Aug 13.

Rama P, Matuska S, Paganoni G, Spinelli A. De Luca M, Pellegrini G. Limbal stem-cell therapy and long-term corneal regeneration. N Engl J Med. 2010 Jul 8;363(2):147-55. doi: 10.1056/NEJMoa0905955. Epub 2010 Jun 23.

Colabelli Gisoldi RA, Pocobelli A, Villani CM, Amato D, Pellegrini G. Evaluation of molecular markers in corneal regeneration by means of autologous cultures of limbal cells and keratoplasty. Cornea. 2010 Jul;29(7):715-22. doi: 10.1097/ICO.0b013e3181c91ac4.

Xynos A, Corbella P, Belmonte N, Zini R, Manfredini R, Ferrari G. Bone marrow-derived hematopoietic cells undergo myogenic differentiation following a Pax-7 independent pathway. Stem Cells. 2010 May;28(5):965-73. doi: 10.1002/stem.418.

Pellegrini G, De Luca M. Human embryonic stem-cell derived keratinocytes: how close to clinics?. Cell Stem Cell. 2010 Jan 8;6(1):8-9. doi: 10.1016/j.stem.2009.12.002.


2009

Lemoli RM, Fogli M, Bianchi E, Salvestrini V, Salati S, Amabile M, Bertolini F, Tafuri A, Zini R, Testoni N, Rabascio C, Rossi L, Martinelli G, Baccarani M, Ferrari S, Manfredini R. Molecular and functional analysis of stem cell compartment of chronic myelogenous leukemia reveals the presence of a CD34 negative cell population with intrinsic resistance to imatinib treatment. Blood. 2009 Dec 10;114(25):5191-200. doi: 10.1182/blood-2008-08-176016.

Gabriel R, Eckenberg R, Paruzynski A, Bartholomae CC, Nowrouzi A, Arens A, Howe SJ, Recchia A, Cattoglio C, Wang W, Faber K, Schwarzwaelder K, Kirsten R, Deichmann A, Ball CR, Balaggan KS, Yáñez-Muñoz RJ, Ali RR, Gaspar HB, Biasco L, Aiuti A, Cesana D, Montini E, Naldini L, Cohen-Haguenauer O, Mavilio F, Thrasher AJ, Glimm H, von Kalle C, Saurin W, Schmidt M. Comprehensive genomic access to vector integration in clinical gene therapy. Nat Med. 2009 Dec;15(12):1431-6. doi: 10.1038/nm.2057. Epub 2009 Nov 22.

Lambiase A, Micera A, Pellegrini G, Merlo D, Rama P, De Luca M, Bonini S, Bonini S. In vitro evidence of nerve growth factor effects on human conjunctival epithelial cell differentiation and mucin gene expression. Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4622-30. doi: 10.1167/iovs.08-2716. Epub 2009 Apr 30.

Cellai C, Laurenzana A, Bianchi E, Sdelci S, Manfredini R, Vannucchi AM, Caporale R, Balliu M, Mannelli F, Ferrari S, Bosi A, Miniati D, Cocco PL, Veronneau S, Stankova J, Paoletti F. Mechanistic insight into WEB-2170-induced apoptosis in human acute myelogenous leukemia cells. the crucial role of PTEN. Exp Hematol. 2009 Oct;37(10):1176-1185.e21. doi: 10.1016/j.exphem.2009.07.002. Epub 2009 Jul 15.

De Luca M, Pellegrini G, Mavilio F. Gene therapy of inherited skin adhesion disorders: A critical overview. Br J Dermatol. 2009 Jul;161(1):19-24. doi: 10.1111/j.1365-2133.2009.09243.x. Epub 2009 Apr 20. 

Catani L, Zini R, Sollazzo D, Ottaviani E, Vannucchi AM, Ferrari S, Baccarani M, Vianelli N, Lemoli RM, Manfredini R. Molecular profile of CD34+ stem/progenitor cells according to JAK2V617F mutation status in essential thrombocythemia. Leukemia. 2009 May;23(5):997-1000. doi: 10.1038/leu.2008.357. Epub 2009 Jan 8.

Maruggi G, Porcellini S, Facchini G, Perna SK, Cattoglio C, Sartori D, Ambrosi A, Schambach A, Baum C, Bonini C, Bovolenta C, Mavilio F, Recchia A. Transcriptional enhancers induce insertional gene deregulation independently from the vector type and design. Mol Ther. 2009 May;17(5):851-6. doi: 10.1038/mt.2009.51. Epub 2009 Mar 17.

Ahrlund-Richter L, De Luca M, Marshak DR, Munsie M, Veiga A, Rao M, Isolation and production of cells suitable for human therapy: challenges ahead. Cell Stem Cell. 2009 Jan 9;4(1):20-6. doi: 10.1016/j.stem.2008.11.012. Epub 2008 Dec 8.

Pellegrini G, Rama P, Mavilio F, De Luca M. Epithelial stem cells in corneal regeneration and epidermal gene therapy. J Pathol. 2009 Jan;217(2):217-28. doi: 10.1002/path.2441.

Recchia A, Mavilio F. Tracking gene-modified T cells in vivo. Methods Mol Biol. 2009;506:391-401. doi: 10.1007/978-1-59745-409-4_26.

Felice B, Cattoglio C, Cittaro D, Testa A, Miccio A, Ferrari G, Luzi L, Recchia A, Mavilio F. Transcription factor binding sites are genetic determinants of retroviral integration in the human genome. PLoS One. 2009;4(2):e4571. doi: 10.1371/journal.pone.0004571. Epub 2009 Feb 24.


2008

Hyun I, Lindvall O, Ahrlund-Richter L, Cattaneo E, Cavazzana-Calvo M, Cossu G, De Luca M, Fox IJ, Gerstle C, Goldstein RA, Hermerén G, High KA, Kim HO, Lee HP, Levy- Lahad E, Li L, Lo B, Marshak DR, McNab A, Munsie M, Nakauchi H, Rao M, Rooke HM, Valles CS, Srivastava A, Sugarman J, Taylor PL, Veiga A, Wong AL, Zoloth L, Daley GQ. New ISSCR Guidelines Underscore Major Principles for Responsible Translational Stem Cell Research. Cell Stem Cell. 2008 Dec 4;3(6):607-9. doi: 10.1016/j.stem.2008.11.009.

De Luca M, Pellegrini G, Mavilio F. Gene therapy of inherited skin adhesion disorders. Drug Discovery Today: Therapeutic Strategies. 2008 Dec;5(4):249-254. Doi: 10.1016/j.ddstr.2009.04.001.

Di Nunzio F, Maruggi G, Ferrari S, Di Iorio E, Poletti V, Garcia M, Del Rio M, De Luca M, Larcher F, Pellegrini G, Mavilio F. Correction of laminin-5 deficiency in human epidermal stem cells by transcriptionally targeted lentiviral vectors. Mol Ther. 2008 Dec;16(12):1977-85. doi: 10.1038/mt.2008.204. Epub 2008 Sep 23.

Vrana NE, Builles N, Justin V, Bednarz J, Pellegrini G, Ferrari B, Damour O, Hulmes DJ, Hasirci V. Development of a reconstructed cornea from collagen-chondroitin sulfate foams and human cell cultures. Invest Ophthalmol Vis Sci. 2008 Dec;49(12):5325-31. doi: 10.1167/iovs.07-1599. Epub 2008 Aug 15.

Vinciguerra P, Albè E, Rosetta P, Di Iorio E, Pellegrini G. Custom phototherapeutic keratectomy and autologous fibrin-cultured limbal stem cell autografting: a combined approach. J Refract Surg. 2008 Apr;24(4):323-4.

Butti E, Bergami A, Recchia A, Brambilla E, Del Carro U, Amadio S, Cattalini A, Esposito M, Stornaiuolo A, Comi G, Pluchino S, Mavilio F, Martino G, Furlan R. IL4 gene delivery to the CNS recruits regulatory T cells and induces clinical recovery in mouse models of multiple sclerosis. Gene Ther. 2008 Apr;15(7):504-15. doi: 10.1038/gt.2008.10. Epub 2008 Jan 31.

Salati S, Zini R, Bianchi E, Testa A, Mavilio F, Manfredini R, Ferrari S. Role of CD34 antigen in myeloid differentiation of human hematopoietic progenitor cells. Stem Cells. 2008 Apr;26(4):950-9. doi: 10.1634/stemcells.2007-0597. Epub 2008 Jan 10.

Guilbaud M, Chadeuf G, Avolio F, Francois A, Moullier P, Recchia A, Salvetti A. Relative influence of the Adeno-Associated Virus (AAV) type 2 p5 element for recombinant AAV vector site-specific integration. J Virol. 2008 Mar;82(5):2590-3. Epub 2007 Dec 19.

Butti E, Bergami A, Recchia A, Brambilla E, Franciotta D, Cattalini A, Stornaiuolo A, Lachapelle F, Comi G, Mavilio F, Martino G, Furlan R, Absence of an intrathecal immune reaction to a helper dependent adenoviral vector delivered into the cerebrospinal fluid of non-human primates. Gene Ther. 2008 Feb;15(3):233-8. Epub 2007 Oct 25.

Conigliaro A, Colletti M, Cicchini C, Guerra MT, Manfredini R, Zini R, Bordoni V, Siepi F, Leopizzi M, Tripodi M, Amicone L. Isolation and characterization of a murine resident liver stem cell. Cell Death Differ. 2008 Jan;15(1):123-33. Epub 2007 Oct 12.