2020

Maurizi E, Schiroli D, Zini R, Limongelli A, Mistò R, Macaluso C, Pellegrini G. A fine-tuned β-catenin regulation during proliferation of corneal endothelial cells revealed using proteomics analysis. Sci Rep. 2020 Aug 14;10(1):13841. doi: 10.1038/s41598-020-70800-w.

Magrelli Federica M, Merra A., Pellegrini G. Surgery Versus ATMPs: An Example From Ophthalmology. Front Bioeng Biotechnol. 2020 Jun 10;8:440. doi: 10.3389/fbioe.2020.00440. eCollection 2020.

De Rosa L, Latella MC, Secone Seconetti A, Cattelani C, Bauer JW, Bondanza S, De Luca M. Toward Combined Cell and Gene Therapy for Genodermatoses. Cold Spring Harb Perspect Biol. 2020 May 1;12(5):a035667. doi: 10.1101/cshperspect.a035667. Epub 2019 Oct 25.


2019

Bassi R, Bucci EM, Calogero R, Carninci P, Ciliberto G, Conte P, De Luca M, Corbellini G, Giordano A, Marchionni L, Massaro Giordano G, Parini A, Sbardella G. Look for methods, not conclusions. Cell Death and Disease 2019 Dec 1;10:931 doi: 10.1038/s41419-019-2179-8

Deng SX, Borderie V, Chan CC, Dana R, Figueiredo FC, Gomes JAP, Pellegrini G, Shimmura S, Kruse FE. Reply. Cornea. 2019 Dec;38(12):e56-e57. doi: 10.1097/ICO.0000000000002145.

Vukasovic A, Asnaghi MA, Kostesic P, Quasnichka H, Cozzolino C, Pusic M, Hails L, Trainor N, Krause C, Figallo E, Filardo G, Kon E, Wixmerten A, Maticic D, Pellegrini G, Kafienah W, Hudetz D, Smith T, Martin I, Ivkovic A, Wendt D. Bioreactor-manufactured cartilage grafts repair acute and chronic osteochondral defects in large animal studies. Cell Prolif. 2019 Nov;52(6):e12653. doi: 10.1111/cpr.12653. Epub 2019 Sep 6. 

Barbalinardo M, Di Giosia M, Polishchuk I, Magnabosco G, Fermani S, Biscarini F, Calvaresi M, Zerbetto F, Pellegrini G, Falini G, Pokroy B, Valle F. Retinoic acid/calcite micro-carriers inserted in fibrin scaffolds modulate neuronal cell differentiation. J Mater Chem B. 2019 Oct 14;7(38):5808-5813. doi: 10.1039/c9tb01148j. Epub 2019 Sep 5.

Sceberras V, Attico E, Bianchi E, Galaverni G, Melonari M, Corradini F, Fantacci M, Ribbene A, Losi L, Balò S, Lazzeri M, Trombetta C, Rizzo M, Manfredini R, Barbagli G, Pellegrini G. Preclinical study for treatment of hypospadias by advanced therapy medicinal products.. World J Urol. 2019 Jul 9. doi: 10.1007/s00345-019-02864-x. [Epub ahead of print]

De Luca M, Aiuti A, Cossu G, Parmar M, Pellegrini G, Robey PG. Advances in stem cell research and therapeutic development. Nat Cell Biol. 2019 Jul;21(7):801-811. doi: 10.1038/s41556-019-0344-z. Epub 2019 Jun 17

De Rosa L, Secone Seconetti A, De Santis G, Pellacani G, Hirsch T, Rothoeft T, Teig N, Pellegrini G, Bauer JW, De Luca M. Laminin 332-Dependent YAP Dysregulation Depletes Epidermal Stem Cells in Junctional Epidermolysis Bullosa. Cell Rep. 2019 May 14;27(7):2036-2049.e6. doi: 10.1016/j.celrep.2019.04.055.

De Pace B, Fiorentini C, Ciardo S1 Chester J, Kaleci S, Veltri T, De Luca M, Pellacani G. Inherited epidermolysis bullosa: description of clinical and subclinical morphological features with optical coherence tomography. J Eur Acad Dermatol Venereol. 2019 Mar;33(3):e120-e123. doi: 10.1111/jdv.15304. Epub 2018 Nov 15.

Deng SX, Borderie V, Chan CC, Dana R, Figueiredo FC, Gomes JAP, Pellegrini G, Shimmura S, Kruse FE; and The International Limbal Stem Cell Deficiency Working Group. Global Consensus on Definition, Classification, Diagnosis, and Staging of Limbal Stem Cell Deficiency. Cornea. 2019 Mar;38(3):364-375. doi: 10.1097/ICO.0000000000001820.

Rossignoli F, Grisendi G, Spano C, Golinelli G, Recchia A, Rovesti G, Orsi G, Veronesi E, Horwitz EM, Dominici M. Inducible Caspase9-mediated suicide gene for MSC-based cancer gene therapy. Cancer Gene Ther. 2019 Feb;26(1-2):11-16. doi: 10.1038/s41417-018-0034-1. Epub 2018 Jun 29.

Recchia A. AAV-CRISPR Persistence in the Eye of the Beholder. Mol Ther. 2019 Jan 2;27(1):12-14. doi: 10.1016/j.ymthe.2018.12.007. Epub 2018 Dec 14.

Benati D, Marigo V, Recchia A. CRISPR/Cas9 Gene Editing In Vitro and in Retinal Cells In Vivo. Methods Mol Biol. 2019;1834:59-74. doi: 10.1007/978-1-4939-8669-9_4.


2018

Rossi C, Zini R, Rontauroli S, Ruberti S, Prudente Z, Barbieri G, Bianchi E, Salati S, Genovese E, Bartalucci N, Guglielmelli P, Tagliafico E, Rosti V, Barosi G, Vannucchi AM, Manfredini R; AGIMM (AIRC-Gruppo Italiano Malattie Mieloproliferative) investigators. Role of TGF-β1/miR-382-5p/SOD2 axis in the induction of oxidative stress in CD34+ cells from primary myelofibrosis. Mol Oncol. 2018 Dec;12(12):2102-2123. doi: 10.1002/1878-0261.12387. Epub 2018 Nov 16.

Pellegrini G, De Luca M. Living with Keratinocytes. Stem Cell Reports. 2018 Nov 13;11(5):1026-1033. doi: 10.1016/j.stemcr.2018.10.005.

Chorzalska A, Morgan J, Ahsan N, Treaba DO, Olszewski AJ, Petersen M, Kingston N, Cheng Y, Lombardo K, Schorl C, Yu X, Zini R, Pacilli A, Tepper A, Coburn J, Hryniewicz-Jankowska A, Zhao TC, Oancea E, Reagan JL, Liang O, Kotula L, Quesenberry PJ, Gruppuso PA, Manfredini R, Vannucchi AM, Dubielecka PM. Bone marrow-specific loss of ABI1 induces myeloproliferative neoplasm with features resembling human myelofibrosis. Blood. 2018 Nov 8;132(19):2053-2066. doi: 10.1182/blood-2018-05-848408. Epub 2018 Sep 13.

Benati D, Miselli F, Cocchiarella F, Patrizi C, Carretero M, Baldassarri S, Ammendola V, Has C, Colloca S, Del Rio M, Larcher F, Recchia A. CRISPR/Cas9-Mediated In Situ Correction of LAMB3 Gene in Keratinocytes Derived from a Junctional Epidermolysis Bullosa Patient. Mol Ther. 2018 Nov 7;26(11):2592-2603. doi: 10.1016/j.ymthe.2018.07.024. Epub 2018 Aug 4.

Attico E, Sceberras V, Pellegrini G. Approaches for Effective Clinical Application of Stem Cell Transplantation. Current Transplantation 2018;5(3):244-250. doi: 10.1007/s40472-018-0202-0. Epub 2018 Aug 2

Lincoln V, Cogan J, Hou Y, Hirsch M, Hao M, Alexeev V, De Luca M, De Rosa L, Bauer JW, Woodley DT, Chen M. Gentamicin induces LAMB3 nonsense mutation readthrough and restores functional laminin 332 in junctional epidermolysis bullosa. Proc Natl Acad Sci U S A. 2018 2018 Jul 10;115(28):E6536-E6545. doi: 10.1073/pnas.1803154115. Epub 2018 Jun 26

Stern JH, Tian Y, Funderburgh J, Pellegrini G, Zhang K, Goldberg JL, Ali RR, Young M, Xie Y, Temple S. Regenerating Eye Tissues to Preserve and Restore Vision. Cell Stem Cell. 2018 Jun 1;22(6):834-849. doi: 10.1016/j.stem.2018.05.013

Ricciardi MR, Salvestrini V, Licchetta R, Mirabilii S, Forcato M, Gugliotta G, Salati S, Castagnetti F, Rosti G, Breccia M, Alimena G, Manfredini R, Bicciato S, Lemoli RM, Tafuri A. Differential proteomic profile of leukemic CD34+ progenitor cells from chronic myeloid leukemia patients. Oncotarget. 2018 Apr 24;9(31):21758-21769. doi: 10.18632/oncotarget.24938. eCollection 2018 Apr 24.

Horenstein AL, Chillemi A, Zini R, Quarona V, Bianchi N, Manfredini R, Gambari R, Malavasi F, Ferrari D. Cytokine-Induced Killer Cells Express CD39, CD38, CD203a, CD73 Ectoenzymes and P1 Adenosinergic Receptors. Front Pharmacol. 2018 Apr 20;9:196. doi: 10.3389/fphar.2018.00196. eCollection 2018.

Cortesi F, Delfanti G, Grilli A, Calcinotto A, Gorini F, Pucci F, Lucianò R, Grioni M, Recchia A, Benigni F, Briganti A, Salonia A, De Palma M, Bicciato S, Doglioni C, Bellone M, Casorati G, Dellabona P. Bimodal CD40/Fas-Dependent Crosstalk between iNKT Cells and Tumor-Associated Macrophages Impairs Prostate Cancer Progression. Cell Rep. 2018 Mar 13;22(11):3006-3020. doi: 10.1016/j.celrep.2018.02.058.

Ruberti S, Bianchi E, Guglielmelli P, Rontauroli S, Barbieri G, Tavernari L, Fanelli T, Norfo R, Pennucci V, Fattori GC, Mannarelli C, Bartalucci N, Mora B, Elli L, Avanzini MA, Rossi C, Salmoiraghi S, Zini R, Salati S, Prudente Z, Rosti V, Passamonti F, Rambaldi A, Ferrari S, Tagliafico E, Vannucchi AM, Manfredini R. Involvement of MAF/SPP1 axis in the development of bone marrow fibrosis in PMF patients. Leukemia. 2018 Feb;32(2):438-449. doi: 10.1038/leu.2017.220. Epub 2017 Jul 12.

Benati D, Cocchiarella F, Recchia A. An Efficient In Vitro Transposition Method by a Transcriptionally Regulated Sleeping Beauty System Packaged into an Integration Defective Lentiviral Vector. J. Vis. Exp.(131), 2018 Jan 12;(131), doi:10.3791/56742

Pellegrini G, Ardigò D, Milazzo G, Iotti G, Guatelli P, Pelosi D, De Luca M. Navigating Market Authorization: The Path Holoclar Took to Become the First Stem Cell Product Approved in the European Union. Stem Cells Transl Med. 2018 Jan;7(1):146-154. doi: 10.1002/sctm.17-0003. Epub 2017 Dec 27


2017

Salati S, Prudente Z, Genovese E, Pennucci V, Rontauroli S, Bartalucci N, Mannarelli C, Ruberti S, Zini R, Rossi C, Bianchi E, Guglielmelli P, Tagliafico E, Vannucchi AM, Manfredini R. Calreticulin affects hematopoietic stem/progenitor cell fate by impacting erythroid and megakaryocytic differentiation. Stem Cells Dev. 2017 Dec 19. doi: 10.1089/scd.2017.0137. [Epub ahead of print]

Zini R, Guglielmelli P, Pietra D, Rumi E, Rossi C, Rontauroli S, Genovese E, Fanelli T, Calabresi L, Bianchi E, Salati S, Cazzola M, Tagliafico E, Vannucchi AM, Manfredini R; AGIMM (AIRC Gruppo Italiano Malattie Mieloproliferative) investigators. CALR mutational status identifies different disease subtypes of essential thrombocythemia showing distinct expression profiles. Blood Cancer J. 2017 Dec 8;7(12):638. doi: 10.1038/s41408-017-0010-2.

Catani L, Sollazzo D, Bianchi E, Ciciarello M, Antoniani C, Foscoli L, Caraceni P, Giannone FA, Baldassarre M, Giordano R, Montemurro T, Montelatici E, D’Errico A, Andreone P, Giudice V, Curti A, Manfredini R, Lemoli RM. Molecular and functional characterization of CD133+ stem/progenitor cells infused in patients with end-stage liver disease reveals their interplay with stromal liver cells. Cytotherapy. 2017 Dec;19(12):1447-1461. doi: 10.1016/j.jcyt.2017.08.001. Epub 2017 Sep 14.

Hirsch T, Rothoeft T, Teig N, Bauer JW, Pellegrini G, De Rosa L, Scaglione D, Reichelt J, Klausegger A, Kneisz D, Romano O, Secone Seconetti A, Contin R, Enzo E, Jurman I, Carulli S, Jacobsen F, Luecke T, Lehnhardt M, Fischer M, Kueckelhaus M, Quaglino D, Morgante M, Bicciato S, Bondanza S, De Luca M. Regeneration of the entire human epidermis using transgenic stem cells. Nature. 2017 Nov 16;551(7680):327-332. doi: 10.1038/nature24487. Epub 2017 Nov 8.

Mesiano G, Zini R, Montagner G, Bianchi N, Manfredini R, Chillemi A, Aglietta M, Grignani G, Lampronti I, Fiorino E, Malavasi F, Sangiolo D, Gambari R, Ferrari D. Analytic and Dynamic Secretory Profile of Patient-Derived Cytokine-Induced Killer Cells. Mol Med. 2017 Oct;23:235-246. doi: 10.2119/molmed.2017.00084. Epub 2017 Aug 9.

Salati S, Salvestrini V, Carretta C, Genovese E, Rontauroli S, Zini R, Rossi C, Ruberti S, Bianchi E, Barbieri G, Curti A, Castagnetti F, Gugliotta G, Rosti G, Bergamaschi M, Tafuri A, Tagliafico E, Lemoli R, Manfredini R. Deregulated expression of miR-29a-3p, miR-494-3p and miR-660-5p affects sensitivity to tyrosine kinase inhibitors in CML leukemic stem cells. Oncotarget. 2017 Jul 25;8(30):49451-49469. doi: 10.18632/oncotarget.17706.

Sipp D, Caulfield T, Kaye J, Barfoot J, Blackburn C, Chan S, De Luca M, Kent A, McCabe C, Munsie M, Sleeboom-Faulkner M, Sugarman J, van Zimmeren E, Zarzeczny A, Rasko JEJ. Marketing of unproven stem cell-based interventions: A call to action. Sci Transl Med. 2017 Jul 5;9(397). pii: eaag0426. doi: 10.1126/scitranslmed.aag0426

Rama P, Ferrari G, Pellegrini G. Cultivated limbal epithelial transplantation. Curr Opin Ophthalmol. 2017 Jul;28(4):387-389. doi: 10.1097/ICU.0000000000000382

Latella MC, Cocchiarella F, De Rosa L, Turchiano G, Gonçalves MA, Larcher F, De Luca M, Recchia A. Correction of recessive dystrophic epidermolysis bullosa by transposon-mediated integration of COL7A1 in transplantable patient-derived primary keratinocytes. J Invest Dermatol. 2017 Apr; 137(4):836-44. Epub 2016 Dec 24

Rontauroli S, Norfo R, Pennucci V, Zini R, Ruberti S, Bianchi E, Salati S, Prudente Z, Rossi C, Rosti V, Guglielmelli P, Barosi G, Vannucchi A, Tagliafico E, Manfredini R. miR-494-3p overexpression promotes megakaryocytopoiesis in primary myelofibrosis hematopoietic stem/progenitor cells by targeting SOCS6. Oncotarget. 2017 Mar 28;8(13):21380-21397. doi: 10.18632/oncotarget.15226.

Bianchi E, Ruberti S, Rontauroli S, Guglielmelli P, Salati S, Rossi C, Zini R, Tagliafico E, Vannucchi AM, Manfredini R. Role of miR-34a-5p in Hematopoietic Progenitor Cells Proliferation and Fate Decision: Novel Insights into the Pathogenesis of Primary Myelofibrosis. Int J Mol Sci. 2017 Jan 13;18(1). pii: E145. doi: 10.3390/ijms18010145.

Bauer JW, Koller J, Murauer EM, De Rosa L, Enzo E, Carulli S, Bondanza S, Recchia A, Muss W, Diem A, Mayr E, Schlager P, Gratz IK, Pellegrini G, De Luca M. Closure of a large chronic wound through transplantation of gene-corrected epidermal stem cells. J Invest Dermatol. 2017 Mar;137(3):778-781. doi: 10.1016/j.jid.2016.10.038. Epub 2016 Nov 10


2016

Barbagli G, Pellegrini G, Corradini F, Montorsi F, Sansalone S, Butnaru D, Lazzeri M. One-stage Penile Urethroplasty Using Oral Mucosal Graft and Glue. Eur Urol. 2016 Dec;70(6):1069-1075. doi: 10.1016/j.eururo.2016.04.025. Epub 2016 May 6

Bernardis I, Chiesi L, Tenedini E, Artuso L, Percesepe A, Artusi V, Simone ML, Manfredini R, Camparini M, Rinaldi C, Ciardella A, Graziano C, Balducci N, Tranchina A, Cavallini GM, Pietrangelo A, Marigo V, Tagliafico E. Unravelling the Complexity of Inherited Retinal Dystrophies Molecular Testing: Added Value of Targeted Next-Generation Sequencing. Biomed Res Int 2016; 2016: 6341870. doi: 10.1155/2016/6341870. Epub 2016 Dec 29

Latella MC, Di Salvo MT, Cocchiarella F, Benati D, Grisendi G, Comitato A, Marigo V, Recchia A. In vivo Editing of the Human Mutant Rhodopsin Gene by Electroporation of Plasmid-based CRISPR/Cas9 in the Mouse Retina.Mol Ther Nucleic Acids. 2016 Nov 22;5(11):e389. doi: 10.1038/mtna.2016.92. 

Zini R, Rossi C, Norfo R, Pennucci V, Barbieri G, Ruberti S, Rontauroli S, Salati S, Bianchi E, Manfredini R. miR-382-5p Controls Hematopoietic Stem Cell Differentiation Through the Downregulation of MXD1. Stem Cells Dev 2016 Oct; 25: 1433-43. doi: 10.1089/scd.2016.0150. Epub 2016 Sep 7

Rotunno G, Pacilli A, Artusi V, Rumi E, Maffioli M, Delaini F, Brogi G, Fanelli T, Pancrazzi A, Pietra D, Bernardis I, Belotti C, Pieri L, Sant’Antonio E, Salmoiraghi S, Cilloni D, Rambaldi A, Passamonti F, Barbui T, Manfredini R, Cazzola M, Tagliafico E, Vannucchi AM, Guglielmelli P. Epidemiology and clinical relevance of mutations in post-polycythemia vera and post-essential thrombocythemia myelofibrosis. A study on 359 patients of the AGIMM group. Am J Hematol. 2016 Jul;91(7):681-6. doi: 10.1002/ajh.24377. Epub 2016 May 11

Tomasella A, Picco R, Ciotti S, Sgorbissa A, Bianchi E, Manfredini R, Benedetti F, Trimarco V, Frezzato F, Trentin L, Semenzato G, Delia D, Brancolini C. The isopeptidase inhibitor 2cPE triggers proteotoxic stress and ATM activation in chronic lymphocytic leukemia cells. Oncotarget. 2016 Jul 19;7(29):45429-45443. doi: 10.18632/oncotarget.9742.

Milazzo G, Ardigò D, Toschi M, Matuska S, Rama P, De Luca M, Pellegrini G. Holoclar: first of its kind in more ways than one. Cell Gene Therapy Insights 2016 July 6;2(2):183-197. doi:10.18609/cgti.2016.023

Calura E, Pizzini S, Bisognin A, Sales G, Coppe A, Gaffo E, Fanelli T, Mannarelli C, Zini R, Norfo R, Pennucci V, Manfredini R, Romualdi C, Guglielmelli P, Vannucchi AM and Bortoluzzi S. A data-driven network model of primary myelofibrosis: transcriptional and post-transcriptional alterations in CD34+ cells. Blood Cancer J. 2016 Jun 24;6(6):e439. doi: 10.1038/bcj.2016.47

Cocchiarella F, Latella MC, Basile V, Miselli F, Galla M, Imbriano C, Recchia A. Transcriptionally regulated and nontoxic delivery of the hyperactive Sleeping Beauty Transposase. Mol Ther Methods Clin Dev. 2016 Jun 15;3:16038. doi: 10.1038/mtm.2016.38. eCollection 2016.

Cossu G, Buccione R, De Luca M. A discussion on cell therapy in Manchester. Stem Cell Res. 2016 May;16(3):614-6. doi: 10.1016/j.scr.2016.03.005. Epub 2016 Mar 21.

Pellegrini G, Lambiase A, Macaluso C, Pocobelli A, Deng S, Cavallini GM, Esteki R, Rama P, From discovery to approval of an advanced therapy medicinal product-containing stem cells, in the EU. Regen Med. 2016 Jun;11(4):407-20. doi: 10.2217/rme-2015-0051. Epub 2016 Apr 19.

Salati S, Zini R, Nuzzo S, Guglielmelli P, Pennucci V, Prudente Z, Ruberti S, Rontauroli S, Norfo R, Bianchi E, Bogani C, Rotunno G, Fanelli T, Mannarelli C, Rosti V, Salmoiraghi S, Pietra D, Ferrari S, Barosi G, Rambaldi A, Cazzola M, Bicciato S, Tagliafico E, Vannucchi AM, Manfredini R; AGIMM (AIRC Gruppo Italiano Malattie Mieloproliferative) investigators. Integrative analysis of copy number and gene expression data suggests novel pathogenetic mechanisms in Primary Myelofibrosis. Int J Cancer. 2016 Apr 1;138(7):1657-69. doi: 10.1002/ijc.29920. Epub 2015 Nov 25

Bianchi E, Norfo R, Pennucci V, Zini R, Manfredini R. Genomic landscape of megakaryocytopoiesis and platelet function defects. Blood. 2016 Mar 10;127(10):1249-59. doi: 10.1182/blood-2015-07-607952. Epub 2016 Jan 19

Corradini F, Zattoni M, Barbagli G, Bianchi G, Giovanardi M, Serafini C, Genna V, Ribbene A, Balò S, Fidanza F, Lazzeri M, De Luca M, Pellegrini G. Comparative Assessment Of Cultures From Oral And Urethral Stem Cells For Urethral Regeneration. Curr Stem Cell Res Ther. 2016; 11(8):643-65. doi: 10.2174/1574888X10666150902094644 Epub 2015 Sep 1


2015

Murauer EM, Koller U, Pellegrini G, De Luca M, Bauer JW, Advances in Gene/Cell Therapy in Epidermolysis Bullosa, Keio J Med. 2015 Jun 25;64(2):21-5. doi: 10.2302/kjm.2014-0013-RE. Epub 2015 Jun 6

Marini B, Kertesz-Farkas A, Ali H, Lucic B, Lisek K, Manganaro L, Pongor S, Luzzati R, Recchia A, Mavilio F, Giacca M, Lusic M. Nuclear architecture dictates HIV-1 integration site selection. Nature. 2015 May 14;521(7551):227-31. doi: 10.1038/nature14226. Epub 2015 Mar 2.

Tenedini E, Artuso L, Bernardis I, Artusi V, Percesepe A, De Rosa L, Contin R, Manfredini R, Pellecani G, Giannetti A, Pagani J, De Luca M, Tagliafico E. Amplicon-based NGS: an effective approach for the molecular diagnosis of Epidermolysis Bullosa. Br J Dermatol. 2015  Sep;173(3):731-8. doi: 10.1111/bjd.13858. Epub 2015 Jul 29.

Bianchi E, Bulgarelli J, Ruberti S, Rontauroli S, Sacchi G, Norfo R, Pennucci V, Zini R, Salati S, Prudente Z, Ferrari S, Manfredini R, MYB controls erythroid versus megakaryocyte lineage fate decision through the miR-486-3p-mediated down-regulation of MAF. Cell Death Differ, 2015 Dec;22(12):1906-21. doi: 10.1038/cdd.2015.30. Epub 2015 Apr 10

Droz-Georget Lathion S, Rochat A, Knott G, Recchia A, Martinet D, Benmohammed S, Grasset N, Zaffalon A, Besuchet Schmutz N, Savioz-Dayer E, Beckmann JS, Rougemont J, Mavilio F, Barrandon Y. A single epidermal stem cell strategy for safe ex vivo gene therapy. EMBO Mol Med. 2015 Feb 27;7(4):380-93. doi: 10.15252/emmm.201404353

Pennucci V, Zini R, Norfo R, Guglielmelli P, Bianchi E, Salati S, Sacchi G, Prudente Z, Tenedini E, Ruberti S, Paoli C, Fanelli T, Mannarelli C, Tagliafico E, Ferrari S, Vannucchi AM,  Manfredini R. Abnormal expression patterns of WT1-as, MEG3 and ANRIL long non-coding RNAs in CD34+ cells from patients with primary myelofibrosis and their clinical correlations. Leuk Lymphoma. 2015 Feb;56(2):492-6. doi: 10.3109/10428194.2014.910661. Epub 2014 Jun 16.


2014

Ianiro A, Giosia MD, Fermani S, Samorì C, Barbalinardo M, Valle F, Pellegrini G, Biscarini F, Zerbetto F, Calvaresi M, Falini G. Customizing properties of β-chitin in squid pen (gladius) by chemical treatments. Mar Drugs. 2014 Dec 15;12(12):5979-92. doi: 10.3390/md12125979.

Turchiano G, Latella MC, Gogol-Döring A, Cattoglio C, Mavilio F, Izsvák Z, Ivics Z, Recchia A. Genomic analysis of Sleeping Beauty transposon integration in human somatic cells. PLoS One. 2014 Nov 12;9(11):e112712. doi: 10.1371/journal.pone.0112712. eCollection 2014.

Duarte B, Miselli F, Murillas R, Espinosa-Hevia L, Cigudosa JC, Recchia A, Del Río M, Larcher F. Long-term skin regeneration from a gene-targeted human epidermal stem cell clone. Mol. Ther. 2014 Nov;22(11):1878-80. doi: 10.1038/mt.2014.187.

Norfo R, Zini R, Pennucci V, Bianchi E, Salati S, Guglielmelli P, Bogani C, Fanelli T, Mannarelli C, Rosti V, Pietra D, Salmoiraghi S, Bisognin A, Ruberti S, Rontauroli S, Sacchi G, Prudente Z, Barosi G, Cazzola M, Rambaldi A, Bortoluzzi S, Ferrari S, Tagliafico E, Vannucchi AM, Manfredini R. miRNA-mRNA integrative analysis in primary myelofibrosis CD34+ cells unveils the role of miR-155/JARID2 axis in abnormal megakaryopoiesis. Blood. 2014 Sep 25;124(13):e21-32. doi: 10.1182/blood-2013-12-544197. Epub 2014 Aug 5.

Vannucchi AM, Rotunno G, Bartalucci N, Raugei G, Carrai V, Balliu M, Mannarelli C, Pacilli A, Calabresi L, Fjerza R, Pieri L, Bosi A, Manfredini R, Guglielmelli P. Calreticulin mutation-specific immunostaining in myeloproliferative neoplasms: pathogenetic insight and diagnostic value. Leukemia. 2014 2014 Sep;28(9):1811-8. doi: 10.1038/leu.2014.100. Epub 2014 Mar 12.

Guglielmelli P, Lasho TL, Rotunno G, Score J, Mannarelli C, Pancrazzi A, Biamonte F, Pardanani A, Zoi K, Reiter A, Duncombe A, Fanelli T, Pietra D, Rumi E, Finke C, Gangat N, Ketterling RP, Knudson RA, Hanson CA, Bosi A, Pereira A, Manfredini R, Cervantes F, Barosi G, Cazzola M, Cross NC, Vannucchi AM, Tefferi A. The number of prognostically detrimental mutations and prognosis in primary myelofibrosis: an international study of 797 patients. Leukemia. 2014 Sep;28(9):1804-10. doi: 10.1038/leu.2014.76. Epub 2014 Feb 19.

Cavallini GM, Pellegrini G, Volante V, Ducange P, De Maria M, Torlai G, Benatti C, Forlini M, Chemical injury treated with autologous limbal epithelial stem cell transplantation and subconjunctival bevacizumab, Clinical Ophthalmology, 2014 August 30;8:1671–1673 doi: 10.2147/OPTH.S65298. eCollection 2014.

Pellegrini G, De Luca M, Eyes on the prize: limbal stem cells and corneal restoration, Cell Stem Cell. 2014 Aug 7;15(2):121-2. doi: 10.1016/j.stem.2014.07.011.

Courtney DG, Atkinson SD, Allen EH, Moore JE, Walsh CP, Leslie Pedrioli DM, Macewen CJ, Pellegrini G, Maurizi E, Serafini C, Fantacci M, Liao H, Irvine AD, McLean WH, Moore TC. siRNA Silencing of the Mutant Keratin 12 Allele in Corneal Limbal Epithelial Cells Grown from Patients with Meesmann’s Epithelial Corneal Dystrophy. Invest Ophthalmol Vis Sci. 2014 May 6;55(5):3352-60. doi: 10.1167/iovs.13-12957.

Tenedini E, Bernardis I, Artusi V, Artuso L, Roncaglia E, Guglielmelli P, Pieri L, Bogani C, Biamonte F, Rotunno G, Mannarelli C, Bianchi E, Pancrazzi A, Fanelli T, Malagoli Tagliazucchi G, Ferrari S, Manfredini R, Vannucchi AM, Tagliafico E. Targeted cancer exome sequencing reveals recurrent mutations in myeloproliferative neoplasms, Leukemia. 2014 May;28(5):1052-9. doi: 10.1038/leu.2013.302. Epub 2013 Oct 22.

Guglielmelli P, Biamonte F,  Rotunno G, Artusi V, Artuso L,  Bernardis I, Tenedini E, Pieri L, Paoli C, Mannarelli C, Fjerza R, Rumi E, Stalbovskaya V, Squires M, Cazzola M, Manfredini R, Harrison C, Tagliafico E, Vannucchi AM.  Impact of mutational status on outcomes in myelofibrosis patients treated with ruxolitinib in the COMFORT-II study.  Blood. 2014 Apr 3;123(14):2157-60. doi: 10.1182/blood-2013-11-536557. Epub 2014 Jan 23.

Bianco P, Cattaneo E, De Luca M, Pani L. Stamina therapies: Let the record stand. Nature. 2014 Feb 27;506(7489):434. doi: 10.1038/506434c.

Courtney DG, Atkinson SD, Moore JE, Maurizi E, Serafini C, Pellegrini G, Black GC, Manson F, Yam GH, Allen EH, McLean WH, Moore TC. Development of allele specific gene silencing siRNAs for TGFBI Arg124Cys in Lattice Corneal Dystrophy Type I. Invest Ophthalmol Vis Sci. 2014 Feb 18;55(2):977-85. doi: 10.1167/iovs.13-13279

Pellegrini G, Rama P, Di Rocco A, Panaras A, De Luca M. Concise review: hurdles in a successful example of limbal stem cell-based regenerative medicine. Stem Cells. 2014 Jan;32(1):26-34. doi: 10.1002/stem.1517.

De Rosa L, Carulli S,  Cocchiarella F, Quaglino D, Enzo E, Franchini E, Giannetti A, De Santis G, Recchia A, Pellegrini G, De Luca M. Long-term stability and safety of transgenic cultured epidermal stem cells in gene therapy of junctional epidermolysis bullosa. Stem Cell Reports. 2014 Jan 14;2(1):1-8. doi: 10.1016/j.stemcr.2013.11.001. eCollection 2014.


2013

Coluccio A, Miselli F, Lombardo A, Marconi A, Malagoli Tagliazucchi G, Gonçalves MA, Pincelli C, Maruggi G, Del Rio M, Naldini L, Larcher F, Mavilio F, Recchia A. Targeted gene addition in human epithelial stem cells by zinc-finger nuclease-mediated homologous recombination. Mol Ther. 2013 Sep;21(9):1695-704. doi: 10.1038/mt.2013.143. Epub 2013 Jun 13.

Pellegrini G, Rama P, Matuska S, Lambiase A, Bonini B, Pocobelli A, Gisoldi Colabelli R, Spadea L, Fasciani R, Ballestrazzi E, Vinciguerra P, Rosetta P, Tortori A, Nardi M, Gabbriellini G, Traverso CE., Macaluso C, Losi L, Percesepe A, Venturi B, Corradini F, Panaras A, Di Rocco A, Guatelli P, De Luca M. Biological parameters determining the clinical outcome of cultured limbal stem cells. Regen Med. 2013 Sep;8(5):553-67. doi: 10.2217/rme.13.43. Epub 2013 Jun 3.

Vannucchi AM, Lasho TL, Guglielmelli P, Biamonte F, Pardanani A, Pereira A, Finke C, Score J, Gangat N, Mannarelli C, Ketterling RP, Rotunno G, Knudson RA, Susini MC, Laborde RR, Spolverini A, Pancrazzi A, Pieri L, Manfredini R, Tagliafico E, Zini R, Jones A, Zoi K, Reiter A, Duncombe A, Pietra D, Rumi E, Cervantes F, Barosi G, Cazzola M, Cross NC, Tefferi A. Mutations and prognosis in primary myelofibrosis. Leukemia. 2013 Sep;27(9):1861-9. doi: 10.1038/leu.2013.119. Epub 2013 Apr 26.

André-Schmutz I, Dal-Cortivo L, Six E, Kaltenbach S, Cocchiarella F, Le Chenadec J, Cagnard N, Cordier AG, Benachi A, Mandelbrot L, Azria E, Bouallag N, Luce S, Ternaux B, Reimann C, Revy P, Radford-Weiss I, Leschi C, Recchia A, Mavilio F, Cavazzana M, Blanche S. Genotoxic signature in cord blood cells of newborns exposed in utero to a Zidovudine-based antiretroviral combination. J Infect Dis. 2013 Jul 15;208(2):235-43. doi: 10.1093/infdis/jit149. Epub 2013 Apr 4.

Carulli S, Contin R, De Rosa L, Pellegrini G, De Luca M. The long and winding road that leads to a cure for epidermolysis bullosa. Regen Med. 2013 Jul;8(4):467-81. doi: 10.2217/rme.13.33.

Bianco P, Barker R, Brüstle O, Cattaneo E, Clevers H, Daley GQ, De Luca M, Goldstein L, Lindvall O, Mummery C, Robey PG, Sattler de Sousa E Brito C, Smith A. Regulation of stem cell therapies under attack in Europe: for whom the bell tolls. EMBO J. 2013 May 29;32(11):1489-95. doi: 10.1038/emboj.2013.114. Epub 2013 May 3.

Ciciarello M, Zini R, Rossi L, Salvestrini V, Ferrari D, Manfredini R, Lemoli RM. Extracellular purines promote the differentiation of human bone marrow-derived mesenchymal stem cells to the osteogenic and adipogenic lineages. Stem Cells Dev. 2013 Apr 1;22(7):1097-111. doi: 10.1089/scd.2012.0432. Epub 2012 Dec 21.

Holkers M, Maggio I, Liu J, Janssen JM, Miselli F, Mussolino C, Recchia A, Cathomen T, Gonçalves MA. Differential integrity of TALE nuclease genes following adenoviral and lentiviral vector gene transfer into human cells. Nucleic Acids Res. 2013 Mar 1;41(5):e63. doi: 10.1093/nar/gks1446. Epub 2012 Dec 28.

Cieri N, Camisa B, Cocchiarella F, Forcato M, Oliveira  G, Provasi E, Bondanza A, Bordignon C, Peccatori J, Ciceri F, Lupo-Stanghellini MT, Mavilio F, Mondino A, Bicciato S, Recchia A, Bonini C. IL-7 and IL-15 instruct the generation of human memory stem T cells from naïve precursors. Blood. 2013 Jan 24;121(4):573-84. doi: 10.1182/blood-2012-05-431718. Epub 2012 Nov 15.

Salati S, Lisignoli G, Manferdini C, Pennucci V, Zini R, Bianchi E, Norfo R, Facchini A, Ferrari S, Manfredini R. Co-culture of hematopoietic stem/progenitor cells with human osteblasts favours mono/macrophage differentiation at the expense of the erythroid lineage. PLoS One. 2013;8(1):e53496. doi: 10.1371/journal.pone.0053496. Epub 2013 Jan 22.


2012

Zini R, Norfo R, Ferrari F, Bianchi E, Salati S, Pennucci V, Sacchi G, Carboni C, Ceccherelli GB, Tagliafico E, Ferrari S, Manfredini R. Valproic acid triggers erythro/megakaryocyte lineage decision through induction of GFI1B and MLLT3 expression. Exp Hematol. 2012 Dec;40(12):1043-1054.e6. doi: 10.1016/j.exphem.2012.08.003. Epub 2012 Aug 10.

De Rosa L, De Luca M. Cell biology: Dormant and restless skin stem cells. Nature. 2012 Sep 13;489(7415):215-7. doi: 10.1038/489215a.

Bortoluzzi S, Bisognin A, Biasolo M, Guglielmelli P, Biamonte F, Norfo R, Manfredini R, Vannucchi AM. Characterization and discovery of novel miRNAs and moRNAs in JAK2V617F-mutated SET2 cells. Blood. 2012 Mar 29;119(13):e120-30. doi: 10.1182/blood-2011-07-368001. Epub 2012 Jan 5.

Salvestrini V, Zini R, Rossi L, Gulinelli S, Manfredini R, Bianchi E, Piacibello W, Caione L, Migliardi G, Ricciardi MR, Tafuri A, Romano M, Salati S, Di Virgilio F, Ferrari S, Baccarani M., Ferrari D, Lemoli RM. Purinergic signaling inhibits human acute myeloblastic leukemia cell proliferation, migration and engraftment in immunodeficient mouse, Blood. 2012 Jan 5;119(1):217-26. doi: 10.1182/blood-2011-07-370775. Epub 2011 Nov 3.

Corradini F, Venturi B, Pellegrini G, De Luca M. Methods for characterization/manipulation of human corneal stem cells and their applications in regenerative medicine. Methods Mol Biol. 2012;916:357-72. doi: 10.1007/978-1-61779-980-8_26.


2011

Recchia A, Mavilio F. Site-specific integration by the adeno-associated virus rep protein. Curr Gene Ther. 2011 Oct;11(5):399-405.

Ferrari D, Gulinelli S, Salvestrini V, Lucchetti G, Zini R, Manfredini R, Caione L, Piacibello W, Ciciarello M, Rossi L, Idzko M, Ferrari S, Di Virgilio F, Lemoli RM. Purinergic stimulation of human mesenchymal stem cells potentiates their chemotactic response to CXCL12 and increases the homing capacity and production of proinflammatory cytokines. Exp Hematol. 2011 Mar;39(3):360-74, 374.e1-5. doi: 10.1016/j.exphem.2010.12.001. Epub 2010 Dec 9.

Pellegrini G, Rama P, De Luca M. Vision from the right stem. Trends Mol Med. 2011 Jan;17(1):1-7 Epub 2010 Nov 11

Saghizadeh M, Soleymani S, Harounian A, Bhakta B, Troyanovsky SM, Brunken WJ, Pellegrini G, Ljubimov AV . Alterations of epithelial stem cell marker patterns in human diabetic corneas and effects of c-met gene therapy. Mol Vis. 2011;17:2177-90. Epub 2011 Aug 12.


2010

Cattoglio C, Maruggi G, Bartholomae C, Malani N, Pellin D, Cocchiarella F, Magnani Z, Ciceri F, Ambrosi A, von Kalle C, Bushman FD, Bonini C, Schmidt M, Mavilio F, Recchia A. High-definition mapping of retroviral integration sites defines the fate of allogeneic T cells after donor lymphocyte infusion. PLoS One. 2010 Dec 22;5(12):e15688. doi: 10.1371/journal.pone.0015688.

Bianchi E, Zini R, Salati S, Tenedini E, Norfo R, Tagliafico E, Manfredini R, Ferrari S. c-myb supports erythropoiesis through the transactivation of KLF1 and LMO2 expression. Blood. 2010 Nov 25;116(22):e99-110. doi: 10.1182/blood-2009-08-238311. Epub 2010 Aug 4.

Builles N, Janin-Manificat H, Malbouyres M, Justin V, Rovère MR, Pellegrini G, Torbet J, Hulmes DJ, Burillon C, Damour O, Ruggiero F. Use of magnetically oriented orthogonal collagen scaffolds for hemi-corneal reconstruction and regeneration. Biomaterials. 2010 Nov;31(32):8313-22. doi: 10.1016/j.biomaterials.2010.07.066. Epub 2010 Aug 13.

Rama P, Matuska S, Paganoni G, Spinelli A. De Luca M, Pellegrini G. Limbal stem-cell therapy and long-term corneal regeneration. N Engl J Med. 2010 Jul 8;363(2):147-55. doi: 10.1056/NEJMoa0905955. Epub 2010 Jun 23.

Colabelli Gisoldi RA, Pocobelli A, Villani CM, Amato D, Pellegrini G. Evaluation of molecular markers in corneal regeneration by means of autologous cultures of limbal cells and keratoplasty. Cornea. 2010 Jul;29(7):715-22. doi: 10.1097/ICO.0b013e3181c91ac4.

Xynos A, Corbella P, Belmonte N, Zini R, Manfredini R, Ferrari G. Bone marrow-derived hematopoietic cells undergo myogenic differentiation following a Pax-7 independent pathway. Stem Cells. 2010 May;28(5):965-73. doi: 10.1002/stem.418.

Pellegrini G, De Luca M. Human embryonic stem-cell derived keratinocytes: how close to clinics?. Cell Stem Cell. 2010 Jan 8;6(1):8-9. doi: 10.1016/j.stem.2009.12.002.


2009

Lemoli RM, Fogli M, Bianchi E, Salvestrini V, Salati S, Amabile M, Bertolini F, Tafuri A, Zini R, Testoni N, Rabascio C, Rossi L, Martinelli G, Baccarani M, Ferrari S, Manfredini R. Molecular and functional analysis of stem cell compartment of chronic myelogenous leukemia reveals the presence of a CD34 negative cell population with intrinsic resistance to imatinib treatment. Blood. 2009 Dec 10;114(25):5191-200. doi: 10.1182/blood-2008-08-176016.

Gabriel R, Eckenberg R, Paruzynski A, Bartholomae CC, Nowrouzi A, Arens A, Howe SJ, Recchia A, Cattoglio C, Wang W, Faber K, Schwarzwaelder K, Kirsten R, Deichmann A, Ball CR, Balaggan KS, Yáñez-Muñoz RJ, Ali RR, Gaspar HB, Biasco L, Aiuti A, Cesana D, Montini E, Naldini L, Cohen-Haguenauer O, Mavilio F, Thrasher AJ, Glimm H, von Kalle C, Saurin W, Schmidt M. Comprehensive genomic access to vector integration in clinical gene therapy. Nat Med. 2009 Dec;15(12):1431-6. doi: 10.1038/nm.2057. Epub 2009 Nov 22.

Lambiase A, Micera A, Pellegrini G, Merlo D, Rama P, De Luca M, Bonini S, Bonini S. In vitro evidence of nerve growth factor effects on human conjunctival epithelial cell differentiation and mucin gene expression. Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4622-30. doi: 10.1167/iovs.08-2716. Epub 2009 Apr 30.

Cellai C, Laurenzana A, Bianchi E, Sdelci S, Manfredini R, Vannucchi AM, Caporale R, Balliu M, Mannelli F, Ferrari S, Bosi A, Miniati D, Cocco PL, Veronneau S, Stankova J, Paoletti F. Mechanistic insight into WEB-2170-induced apoptosis in human acute myelogenous leukemia cells. the crucial role of PTEN. Exp Hematol. 2009 Oct;37(10):1176-1185.e21. doi: 10.1016/j.exphem.2009.07.002. Epub 2009 Jul 15.

De Luca M, Pellegrini G, Mavilio F. Gene therapy of inherited skin adhesion disorders: A critical overview. Br J Dermatol. 2009 Jul;161(1):19-24. doi: 10.1111/j.1365-2133.2009.09243.x. Epub 2009 Apr 20. 

Catani L, Zini R, Sollazzo D, Ottaviani E, Vannucchi AM, Ferrari S, Baccarani M, Vianelli N, Lemoli RM, Manfredini R. Molecular profile of CD34+ stem/progenitor cells according to JAK2V617F mutation status in essential thrombocythemia. Leukemia. 2009 May;23(5):997-1000. doi: 10.1038/leu.2008.357. Epub 2009 Jan 8.

Maruggi G, Porcellini S, Facchini G, Perna SK, Cattoglio C, Sartori D, Ambrosi A, Schambach A, Baum C, Bonini C, Bovolenta C, Mavilio F, Recchia A. Transcriptional enhancers induce insertional gene deregulation independently from the vector type and design. Mol Ther. 2009 May;17(5):851-6. doi: 10.1038/mt.2009.51. Epub 2009 Mar 17.

Ahrlund-Richter L, De Luca M, Marshak DR, Munsie M, Veiga A, Rao M, Isolation and production of cells suitable for human therapy: challenges ahead. Cell Stem Cell. 2009 Jan 9;4(1):20-6. doi: 10.1016/j.stem.2008.11.012. Epub 2008 Dec 8.

Pellegrini G, Rama P, Mavilio F, De Luca M. Epithelial stem cells in corneal regeneration and epidermal gene therapy. J Pathol. 2009 Jan;217(2):217-28. doi: 10.1002/path.2441.

Recchia A, Mavilio F. Tracking gene-modified T cells in vivo. Methods Mol Biol. 2009;506:391-401. doi: 10.1007/978-1-59745-409-4_26.

Felice B, Cattoglio C, Cittaro D, Testa A, Miccio A, Ferrari G, Luzi L, Recchia A, Mavilio F. Transcription factor binding sites are genetic determinants of retroviral integration in the human genome. PLoS One. 2009;4(2):e4571. doi: 10.1371/journal.pone.0004571. Epub 2009 Feb 24.


2008

Hyun I, Lindvall O, Ahrlund-Richter L, Cattaneo E, Cavazzana-Calvo M, Cossu G, De Luca M, Fox IJ, Gerstle C, Goldstein RA, Hermerén G, High KA, Kim HO, Lee HP, Levy- Lahad E, Li L, Lo B, Marshak DR, McNab A, Munsie M, Nakauchi H, Rao M, Rooke HM, Valles CS, Srivastava A, Sugarman J, Taylor PL, Veiga A, Wong AL, Zoloth L, Daley GQ. New ISSCR Guidelines Underscore Major Principles for Responsible Translational Stem Cell Research. Cell Stem Cell. 2008 Dec 4;3(6):607-9. doi: 10.1016/j.stem.2008.11.009.

De Luca M, Pellegrini G, Mavilio F. Gene therapy of inherited skin adhesion disorders. Drug Discovery Today: Therapeutic Strategies. 2008 Dec;5(4):249-254. Doi: 10.1016/j.ddstr.2009.04.001.

Di Nunzio F, Maruggi G, Ferrari S, Di Iorio E, Poletti V, Garcia M, Del Rio M, De Luca M, Larcher F, Pellegrini G, Mavilio F. Correction of laminin-5 deficiency in human epidermal stem cells by transcriptionally targeted lentiviral vectors. Mol Ther. 2008 Dec;16(12):1977-85. doi: 10.1038/mt.2008.204. Epub 2008 Sep 23.

Vrana NE, Builles N, Justin V, Bednarz J, Pellegrini G, Ferrari B, Damour O, Hulmes DJ, Hasirci V. Development of a reconstructed cornea from collagen-chondroitin sulfate foams and human cell cultures. Invest Ophthalmol Vis Sci. 2008 Dec;49(12):5325-31. doi: 10.1167/iovs.07-1599. Epub 2008 Aug 15.

Vinciguerra P, Albè E, Rosetta P, Di Iorio E, Pellegrini G. Custom phototherapeutic keratectomy and autologous fibrin-cultured limbal stem cell autografting: a combined approach. J Refract Surg. 2008 Apr;24(4):323-4.

Butti E, Bergami A, Recchia A, Brambilla E, Del Carro U, Amadio S, Cattalini A, Esposito M, Stornaiuolo A, Comi G, Pluchino S, Mavilio F, Martino G, Furlan R. IL4 gene delivery to the CNS recruits regulatory T cells and induces clinical recovery in mouse models of multiple sclerosis. Gene Ther. 2008 Apr;15(7):504-15. doi: 10.1038/gt.2008.10. Epub 2008 Jan 31.

Salati S, Zini R, Bianchi E, Testa A, Mavilio F, Manfredini R, Ferrari S. Role of CD34 antigen in myeloid differentiation of human hematopoietic progenitor cells. Stem Cells. 2008 Apr;26(4):950-9. doi: 10.1634/stemcells.2007-0597. Epub 2008 Jan 10.

Guilbaud M, Chadeuf G, Avolio F, Francois A, Moullier P, Recchia A, Salvetti A. Relative influence of the Adeno-Associated Virus (AAV) type 2 p5 element for recombinant AAV vector site-specific integration. J Virol. 2008 Mar;82(5):2590-3. Epub 2007 Dec 19.

Butti E, Bergami A, Recchia A, Brambilla E, Franciotta D, Cattalini A, Stornaiuolo A, Lachapelle F, Comi G, Mavilio F, Martino G, Furlan R, Absence of an intrathecal immune reaction to a helper dependent adenoviral vector delivered into the cerebrospinal fluid of non-human primates. Gene Ther. 2008 Feb;15(3):233-8. Epub 2007 Oct 25.

Conigliaro A, Colletti M, Cicchini C, Guerra MT, Manfredini R, Zini R, Bordoni V, Siepi F, Leopizzi M, Tripodi M, Amicone L. Isolation and characterization of a murine resident liver stem cell. Cell Death Differ. 2008 Jan;15(1):123-33. Epub 2007 Oct 12.


Selezione delle pubblicazioni precedenti più rilevanti

2007

Pellegrini G, De Luca M, Arsenijevic Y. Towards therapeutic application of ocular stem cells. Semin Cell Dev Biol. 2007 Dec;18(6):805-18. doi:10.1016/j.semcdb.2007.09.011. Epub 2007 Sep 16.

Cattoglio C, Facchini G, Sartori D, Antonelli A, Miccio A, Cassani B, Schmidt M, von Kalle C, Howe S, Thrasher AJ, Aiuti A, Ferrari G, Recchia A, Mavilio F. Hot spots of retroviral integration in human CD34+ hematopoietic cells. Blood. 2007 Sep 15;110(6):1770-8. Epub 2007 May 16.

Aiuti A, Cassani B, Andolfi G, Mirolo M, Biasco L, Recchia A, Urbinati F, Valacca C, Scaramuzza S, Cazzola M, Sartori D, Ambrosi A, Di Serio C, Roncarolo MG, Mavilio F, Bordignon C. Multilineage hematopoietic reconstitution without clonal selection in ADA-SCID patients treated with stem cell gene therapy. J Clin Invest. 2007 Aug;117(8):2233-40.

Barbaro V, Testa A, Di Iorio E, Mavilio F, Pellegrini G, De Luca M . C/EBPd regulates cell cycle and self- renewal of human limbal stem cells. J Cell Biol. 2007 Jun 18;177(6):1037-49.  doi:  10.1083/jcb.200703003. Epub 2007 Jun 11.

Guglielmelli P, Zini R, Bogani C, Salati S, Pancrazzi A, Bianchi E, Mannelli F, Ferrari S, Le Bousse-Kerdiles MC, Bosi A, Barosi G, Migliaccio AR, Manfredini R, Vannucchi AM. Molecular profiling of CD34+ cells in idiopathic myelofibrosis identifies a set of disease-associated genes and reveals the clinical significance of Wilms’ tumor gene 1 (WT1). Stem Cells. 2007 Jan;25(1):165-73. Epub 2006 Sep 21.

Magnoni C, Tenedini E, Benassi L, Bernardi C, Gualdi G, Ferrari F, Manfredini R, Bicciato S, Ferrari S, Giannetti A, Tagliafico E. Transcriptional profiles in melanocytes from unaffected skin distinguish the neoplastic growth pattern in patients with melanoma. Br J Dermatol. 2007 Jan;156(1):62-71.

2006

Mavilio F, Pellegrini G, Ferrari S, Di Nunzio F, Di Iorio E, Recchia A, Maruggi G, Ferrari G, Bonini C, Capurro S, Conti A, Magnoni C, Giannetti A, De Luca M. Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells. Nat Med. 2006 Dec;12(12):1397-402. doi:10.1038/nm1504. Epub 2006 Nov 19.

Barbaro V, Di Iorio E, Ferrari S, Bisceglia L, Ruzza A, De Luca M, Pellegrini G. Expression of VSX1 in human corneal keratocytes during differentiation to myofibroblasts in response to wound healing. Invest Ophthalmol Vis Sci. 2006 Dec;47(12):5243-50. doi:10.1167/iovs.06-0185.

Di Iorio E, Barbaro V, Ferrari S, Ortolani C, De Luca M, Pellegrini G. Q-FIHC: quantification of fluorescence immunohistochemistry to analyse p63 isoforms and cell cycle phases in human limbal stem cells. Microsc Res Tech. 2006 Dec;69(12):983-91. doi: 10.1002/jemt.20375.

Vetrini F, Tammaro R, Bondanza S, Surace EM, Auricchio A, De Luca M, Ballabio A, Marigo V. Aberrant splicing in the ocular albinism type 1 gene (OA1/GPR143) is corrected in vitro by morpholino antisense oligonucleotides. Hum Mutat. 2006 May;27(5):420-6.

Ferrari S, Pellegrini G, Matsui T, Mavilio F, De Luca M. Towards a gene therapy clinical trial for epidermolysis bullosa. Rev Recent Clin Trials. 2006 May;1(2):155-62. doi:10.2174/157488706776876472.

Ferrari S, Pellegrini G, Matsui T, Mavilio F, De Luca M. Gene therapy in combination with tissue engineering to treat epidermolysis bullosa. Expert Opin Biol Ther. 2006 Apr;6(4):367-78. 10.1517/14712598.6.4.367.

Recchia A, Bonini C, Magnani Z, Urbinati F, Sartori D, Muraro S, Tagliafico E, Bondanza A, Lupo Stanghellini MT, Bernardi M, Pescarollo A, Ciceri F, Bordignon C, Mavilio F. Retroviral vector integration deregulates gene expression but has no consequence on the biology and function of transplanted T cells. Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1457-62. Epub 2006 Jan 23.

De Luca M, Pellegrini G, Green H. Regeneration of squamous epithelia from stem cells of cultured grafts. Regen Med. 2006 Jan;1(1):45-57. doi:10.2217/17460751.1.1.45.

2005

Volpi N, Maccari F, Ferrari S, De Luca M, Pellegrini G. Separation of keratan-sulfate-derived disaccharides by high-performance liquid chromatography and postcolumn derivatization with 2-cyanoacetamide and fluorimetric detection. Anal Biochem. 2005 Jul 15;342(2):200-5. doi:10.1016/j.ab.2005.04.020.

Di Iorio E, Barbaro V, Ruzza A, Ponzin D, Pellegrini G, De Luca M. Isoforms of DNp63 and the migration of ocular limbal cells in human corneal regeneration. Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9523-8. Epub 2005 Jun 27. doi:10.1073/pnas.0503437102.

Ferrari S, Pellegrini G, Mavilio F, De Luca M. Gene therapy approaches for epidermolysis bullosa. Clin Dermatol. 2005 Jul-Aug;23(4):430-6. doi:10.1016/j.clindermatol.2004.07.017.

Manfredini R, Zini R, Salati S, Siena M, Tenedini E, Tagliafico E, Montanari M, Zanocco-Marani T, Gemelli C, Vignudelli T, Grande A, Fogli M, Rossi L, Fagioli ME, Catani L, Lemoli RM, Ferrari S. The kinetic status of Hemopoietic Stem Cell (HSC) subpopulations underlies a differential expression of genes involved in self-renewal, commitment and engraftment. Stem Cells. 2005 Apr;23(4):496-506.

Lemoli RM, Bertolini F, Cancedda R, De Luca M, Del Santo A, Ferrari G, Ferrari S, Martino G, Mavilio F, Tura S. Stem cell plasticity: time for a reappraisal? Haematologica. 2005 Mar;90(3):360-81.

2004

Pellegrini G, Dellambra E, Paterna P, Golisano O, Traverso CE, Rama P, Lacal P, De Luca M. Telomerase activity is sufficient to bypass replicative senescence in human limbal and conjunctival but not corneal keratinocytes. Eur J Cell Biol. 2004 Dec;83(11-12):691-700. doi:10.1078/0171-9335-00424.

Pellegrini G. Changing the cell source in cell therapy?.  N Engl J Med. 2004 Sep 16;351(12):1170-2. doi: 10.1056/NEJMp048199.

Guerra L, Primavera G, Raskovic D, Pellegrini G, Golisano O, Bondanza S, Kuhn S, Piazza P, Luci A, Atzori F, De Luca M. Permanent repigmentation of piebaldism by erbium:YAG laser and autologous cultured epidermis. Br J Dermatol. 2004 Apr;150(4):715-21. doi:10.1111/j.0007-0963.2004.05500.x.

Abbruzzese C, Kuhn U, Molina F, Rama P, De Luca M. Novel mutations in the CHST6 gene causing macular corneal dystrophy. Clin Genet. 2004 Feb;65(2):120-5.

2003

Guerra L, Primavera G, Raskovic D, Pellegrini G, Golisano O, Bondanza S, Paterna P, Sonego G, Gobello T, Atzori F, Piazza P, Luci A, De Luca M. Erbium:YAG laser and cultured epidermis in the surgical therapy of stable vitiligo. Arch Dermatol. 2003 Oct;139(10):1303-10. doi:10.1001/archderm.139.10.1303.

Quast T, Wehner S, Kirfel G, Jaeger K, De Luca M, Herzog V. sAPP as a regulator of dendrite motility and melanin release in epidermal melanocytes and melanoma cells. FASEB J. 2003 Sep;17(12):1739-41. Epub 2003 Jul 3.

2002

Rheinwald JG, Hahn WC, Ramsey MR, Wu JY, Guo Z, Tsao H, De Luca M, Catricalà C, O’Toole KM. A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status. Mol Cell Biol. 2002 Jul;22(14):5157-72.

Schiaffino MV, Dellambra E, Cortese K, Baschirotto C, Bondanza S, Clementi M, Nucci P, Ballabio A, Tacchetti C, De Luca M. Effective retrovirus-mediated gene transfer in normal and mutant human melanocytes. Hum Gene Ther. 2002 May 20;13(8):947-57.

De Luca M, Dellambra E, Pellegrini G, Guerra L, Bondanza S, Mavilio F. Toward gene therapy of junctional epidermolysis bullosa (JEB). European Journal of Human Genetics. 2002;10: 58.

2001

Rama P, Bonini S, Lambiase A, Golisano O, Paterna P, De Luca M, Pellegrini G. Autologous fibrin-cultured limbal stem cells permanently restore the corneal surface of patients with total limbal stem cell deficiency. Transplantation. 2001 Nov 15;72(9):1478-85.

Dellambra E, Prislei S, Salvati AL, Madeddu ML, Golisano O, Siviero E, Bondanza S, Cicuzza S, Orecchia A, Giancotti FG, Zambruno G, De Luca M. Gene correction of integrin beta4-dependent pyloric atresia-junctional epidermolysis bullosa keratinocytes establishes a role for beta4 tyrosines 1422 and 1440 in hemidesmosome assembly. J Biol Chem. 2001 Nov 2;276(44):41336-42. Epub 2001 Aug 24.

Pellegrini G, Dellambra E, Golisano O, Martinelli E, Fantozzi I, Bondanza S, Ponzin D, McKeon F, De Luca M. p63 identifies keratinocyte stem cells. Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3156-61. doi:10.1073/pnas.061032098.

2000

D’Addio M, Pizzigoni A, Bassi MT, Baschirotto C, Valetti C, Incerti B, Clementi M, De Luca M, Ballabio A, Schiaffino MV. Defective intracellular transport and processing of OA1 is a major cause of ocular albinism type 1. Hum Mol Genet. 2000 Dec 12;9(20):3011-8.

Dellambra E, Pellegrini G, Guerra L, Ferrari G, Zambruno G, Mavilio F, De Luca M. Toward epidermal stem cell-mediated ex vivo gene therapy of junctional epidermolysis bullosa. Hum Gene Ther. 2000 Nov 1;11(16):2283-7. doi:10.1089/104303400750035825.

Taichman LB, Khavari PA, De Luca M. Introductory remarks. Hum Gene Ther. 2000 Nov 1;11(16):2245.

Guerra L, Capurro S, Melchi F, Primavera G, Bondanza S, Cancedda R, Luci A, De Luca M, Pellegrini G. Treatment of “stable” vitiligo by Timedsurgery and transplantation of cultured epidermal autografts. Arch Dermatol. 2000 Nov;136(11):1380-9. doi:10.1001/archderm.136.11.1380.

Dellambra E, Golisano O, Bondanza S, Siviero E, Molinari M, Lacal P, D’Atri S, De Luca M. Downregulation of 14-3-3s prevents clonal evolution and leads to immortalization of primary human keratinocytes. J Cell Biol. 2000 May 29;149(5):1117-30.

Foehr ED, Tatavos A, Tanabe E, Raffioni S, Goetz S, Dimarco E, De Luca M, Bradshaw RA. Discoidin domain receptor 1 (DDR1) signaling in PC12 cells: activation of juxtamembrane domains in PDGFR/DDR/TrkA chimeric receptors. FASEB J. 2000 May;14(7):973-81.

1999

Pellegrini G, Ranno R, Stracuzzi G, Bondanza S, Guerra L, Zambruno G, Micali G, De Luca M. The control of epidermal stem cells (holoclones) in the treatment of massive full-thickness burns with autologous keratinocytes cultured on fibrin. Transplantation. 1999 Sep 27;68(6):868-79.

Chistolini P, De Angelis G, De Luca M, Pellegrini G, Ruspantini I. Analysis of the mechanical properties of in vitro reconstructed epidermis: preliminary results. Med Biol Eng Comput. 1999 Sep;37(5):670-2.

Schiaffino MV, D’Addio M, Alloni A, Baschirotto C, Valetti C, Cortese K, Puri C, Bassi MT, Colla C, De Luca M, Tacchetti C, Ballabio A. Ocular albinism: evidence for a defect in an intracellular signal transduction system. Nat Genet. 1999 Sep;23(1):108-12.

Manfredini R, Trevisan F, Grande A, Tagliafico E, Montanari M, Lemoli R, Visani G, Tura S, Ferrari S, Ferrari S.  Induction of a functional Vitamin D receptor in all-trans retinoic acid-induced monocytic differentiation of M2 type leukemic blast cells. Cancer Res. 1999 Aug 1;59(15):3803-11.

Pellegrini G, Golisano O, Paterna P, Lambiase A, Bonini S, Rama P, De Luca M. Location and clonal analysis of stem cells and their differentiated progeny in the human ocular surface. J Cell Biol. 1999 May 17;145(4):769-82. doi:10.1083/jcb.145.4.769.

1998

Pellegrini G, Bondanza S, Guerra L, De Luca M. Cultivation of human keratinocyte stem cells: current and future clinical applications. Med Biol Eng Comput. 1998 Nov;36(6):778-90.

Vailly J, Gagnoux-Palacios L, Dell’Ambra E, Roméro C, Pinola M, Zambruno G, De Luca M, Ortonne JP, Meneguzzi G. Corrective gene transfer of keratinocytes from patients with junctional epidermolysis bullosa restores assembly of hemidesmosomes in reconstructed epithelia. Gene Ther. 1998 Oct;5(10):1322-32. doi:10.1089/hum.1998.9.9-1359..

Dellambra E, Vailly J, Pellegrini G, Bondanza S, Golisano O, Macchia C, Zambruno G, Meneguzzi G, De Luca M. Corrective transduction of human epidermal stem cells in laminin-5-dependent junctional epidermolysis bullosa. Hum Gene Ther. 1998 Jun 10;9(9):1359-70.

Bellini MH, Mathor MB, De Luca M, Cancedda R, Bartolini P. Ultrasensitive in vivo bioassay detects bioactive human growth hormone in transduced primary human keratinocytes. J Endocrinol Invest. 1998 Jan;21(1):1-6.

1997

Marchisio PC, Trusolino L, De Luca M. Topography and biological role of integrins in human skin. Microsc Res Tech. 1997 Aug 15;38(4):353-60.

Malorni W, Guiducci G, Pasquinelli G, Rivabene R, Re RC., Ramazzotti E, De Luca M, La Placa M, Cenacchi G. HIV-type 1 induces specific cytoskeleton alterations in human epithelial cells in culture. Eur. J. Dermatol. 1997 Jun;7(4): 263-269.

De Luca M, Pellegrini G. The importance of epidermal stem cells in keratinocyte-mediated gene therapy. Gene Ther. 1997 May;4(5):381-3.

Tsubota K, De Luca M, Pellegrini G. Corneal epithelial stem-cell transplantation. Lancet. 1997 May 24; 349:1556.

Pellegrini G, Traverso C, Franzi AT, Zingirian M, Cancedda R, De Luca M. Long-term restoration of damaged corneal surfaces with autologous cultivated corneal epithelium. Lancet 1997 Apr 5;349(9057):990-3. doi:10.1016/S0140-6736(96)11188-0.

Manfredini R, Balestri R, Tagliafico E, Trevisan F, Pizzanelli M, Grande A, Barbieri D, Zucchini P, Citro G, Franceschi C, Ferrari S. Antisense inhibition of c-fes proto-oncogene blocks PMA-induced macrophage differentiation in HL60 and in FDC-P1/MAC-11 cells. Blood. 1997 Jan 1;89(1):135-45.

1996

Mathor MB, Ferrari G, Dellambra E, Cilli M, Mavilio F, Cancedda R, De Luca M. Clonal analysis of stably transduced human epidermal stem cells in culture. Proc Natl Acad Sci U S A. 1996 Sep 17;93(19):10371-6.

Schiaffino MV, Baschirotto C, Pellegrini G, Montalti S, Tacchetti C, De Luca M, Ballabio A. The ocular albinism type 1 gene product is a membrane glycoprotein localized to melanosomes. Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):9055-60.

Cenacchi G, Guiducci G, Pasquinelli G, Re MC, Ramazzotti E, Furlini G, Malorni W, De Luca M, Martinelli GN.  Early ultrastuctural changes of human keratinocytes after HIV-1 contact: an in vitro study. Eur. J. Dermatol. 1996;6(3): 213-218.

1995

Dellambra E, Patrone M, Sparatore B, Negri A, Ceciliani F, Bondanza S, Molina F, Cancedda FD, De Luca M. Stratifin, a keratinocyte specific 14-3-3 protein, harbors a pleckstrin homology (PH) domain and enhances protein kinase C activity. J Cell Sci. 1995 Nov;108 ( Pt 11):3569-79.

Ramarli D, Giri A, Reina S, Poffe O, Cancedda R, Varnier O, Tridente G, De Luca M. HIV-1 spreads from lymphocytes to normal human keratinocytes suitable for autologous and allogenic transplantation. J Invest Dermatol. 1995 Nov;105(5):644-7.

Zambruno G, Marchisio PC, Marconi A, Vaschieri C, Melchiori A, Giannetti A, De Luca M. Transforming growth factor-b1 modulates b1 and b5 integrin receptors and induces the de novo expression of the avb6 heterodimer in normal human keratinocytes: implications for wound healing. J Cell Biol. 1995 May;129(3):853-65.

1994

De Luca M, Pellegrini G, Zambruno G, Marchisio PC. Role of integrins in cell adhesion and polarity in normal keratinocytes and human skin pathologies. J Dermatol. 1994 Nov;21(11):821-8. doi:10.1111/j.1346-8138.1994.tb03296.x.

Giannelli G, Savoia P, Schiraldi O, Lospalluti M, De Luca M, Marchisio PC, Quaranta V. Psoriatic lesions in patients with chronic liver disease are distinct from psoriasis vulgaris lesions, as judged on basis of integrin adhesion receptors. Hepatology. 1994 Jul;20(1 Pt 1):56-65.

Girolomoni G, Zambruno G, Manfredini R, Zacchi V, Ferrari S, Cossarizza A, Giannetti A. Expression of B7 costimulatory molecule in cultured human epidermal Langerhans cells is regulated at mRNA level. J Invest Dermatol. 1994 Jul;103(1):54-9

De Luca M. Keratinocyte-melanocyte interactions in in vitro reconstituted human epidermis. Chron. Derm. 1994;IV:6, 935-940.

1993

Di Marco E, Cutuli N, Guerra L, Cancedda R, De Luca M. Molecular cloning of trkE, a novel trk-related putative tyrosine kinase receptor isolated from normal human keratinocytes and widely expressed by normal human tissues. J Biol Chem. 1993 Nov 15;268(32):24290-5.

Di Marco E, Mathor M, Bondanza S, Cutuli N, Marchisio PC, Cancedda R, De Luca M. Nerve growth factor binds to normal human keratinocytes through high and low affinity receptors and stimulates their growth by a novel autocrine loop. J Biol Chem. 1993 Oct 25;268(30):22838-46.

Romagnoli G, De Luca M, Faranda F, Franzi AT, Cancedda R. One-step treatment of posterior hypospadias by the autologous graft of cultured urethral epithelium. J Urol. 1993 Oct;150(4):1204-7.

Manfredini R, Grande A, Tagliafico E. Barbieri D, Zucchini P, Citro G, Zupi G, Franceschi C, Torelli U, Ferrari S. Inhibition of c-fes expression by an antisense oligomer causes apoptosis of HL60 cells induced to granulocytic differentiation. J Exp Med. 1993 Aug 1;178(2):381-9.

De Luca M, Siegrist W, Bondanza S, Mathor M, Cancedda R, Eberle AN. Alpha melanocyte stimulating hormone (alpha MSH) stimulates normal human melanocyte growth by binding to high-affinity receptors. J Cell Sci. 1993 Aug;105 ( Pt 4):1079-84.

Zambruno G, Marchisio PC, Melchiori A, Bondanza S, Cancedda R, De Luca M. Expression of integrin receptors and their role in adhesion, spreading and migration of normal human melanocytes. J Cell Sci. 1993 May;105 ( Pt 1):179-90.

Marchisio PC, Cremona O, Savoia P, Pellegrini G, Ortonne JP, Verrando P, Burgeson RE, Cancedda R, De Luca M. The basement membrane protein BM-600/nicein codistributes with kalinin and the integrin alpha 6 beta 4 in human cultured keratinocytes. Exp Cell Res. 1993 Apr;205(2):205-12. doi:10.1006/excr.1993.1078

Cancedda R, De Luca M. Tissue engineering for clinical application. Year Immunol. 1993;7:193-8.

1992

Rugolo M, Mastrocola T, De Luca M, Romeo G, Galietta LJ. A volume-sensitive chloride conductance revealed in cultured human keratinocytes by 36Cl- efflux and whole-cell patch clamp recording. Biochim Biophys Acta. 1992 Nov 23;1112(1):39-44.

De Luca M, Pellegrini G, Bondanza S, Cremona O, Savoia P, Cancedda R, Marchisio PC. The control of polarized integrin topography and the organization of adhesion-related cytoskeleton in normal human keratinocytes depend upon number of passages in culture and ionic environment. Exp Cell Res. 1992 Sep;202(1):142-50. doi:10.1016/0014-4827(92)90413-3

Pellegrini G, De Luca M, Orecchia G, Balzac F, Cremona O, Savoia P, Cancedda R., Marchisio PC, Expression, topography and function of integrin receptors is severely altered in keratinocytes from involved and uninvolved psoriatic skin. J Clin Invest. 1992 Jun;89(6):1783-95. doi:10.1172/JCI115782

Barreca A, De Luca M, Del Monte P, Bondanza S, Damonte G, Cariola G, Di Marco E, Giordano G, Cancedda R, Minuto F. In vitro paracrine regulation of human keratinocyte growth by fibroblast-derived insulin-like growth factors. J Cell Physiol. 1992 May;151(2):262-8.

De Luca M, Albanese E, Cancedda R, Viacava A, Faggioni A, Zambruno G, Giannetti A. Treatment of leg ulcers with cryopreserved allogeneic cultured epithelium. A multicenter study. Arch Dermatol. 1992 May;128(5):633-8.

Gherzi R, Melioli G, De Luca M, D’Agostino A, Distefano G, Guastella M, D’Anna F, Franzi AT, Cancedda R. “HepG2/erythroid/brain” type glucose transporter (GLUT1) is highly expressed in human epidermis: keratinocyte differentiation affects GLUT1 levels in reconstituted epidermis. J Cell Physiol. 1992 Mar;150(3):463-74.

De Luca M, Bondanza S, Cancedda R, Tamisani AM, Di Noto C, Muller L, Dioguardi D, Brienza E, Calvario A, Zermani R, et al. Permanent coverage of full skin thickness burns with autologous cultured epidermis and reepithelialization of partial skin thickness lesions induced by allogeneic cultured epidermis: a multicentre study in the treatment of children. Burns. 1992;18 Suppl 1:S16-9.

De Luca M, Cancedda R. Culture of human epithelium. Burns. 1992;18 Suppl 1:S5-10.

Pellegrini G, Gherzi R, Franzi AT, D’Anna F, De Luca M, Cancedda R. In vitro reconstitution of differentiated human epithelia. ATLA. 1992; 20:95-102.

1991

Mastrocola T, De Luca M, Rugolo M. Characterization of chloride transport pathways in cultured human keratinocytes. Biochim Biophys Acta. 1991 Nov 21;1097(4):275-82.

Di Marco E, Marchisio PC, Bondanza S, Franzi AT, Cancedda R, De Luca M. Growth-regulated synthesis and secretion of biologically active nerve growth factor by human keratinocytes. J Biol Chem. 1991 Nov 15;266(32):21718-22. 

Gherzi R, Melioli G, De Luca M, D’Agostino A, Guastella M, Traverso CE, D’Anna F, Franzi AT, Cancedda R. High expression levels of the “erythroid/brain” type glucose transporter (GLUT1) in the basal cells of human eye conjunctiva and oral mucosa reconstituted in culture. Exp Cell Res. 1991 Jul;195(1):230-6.

Galietta LJ, Barone V, De Luca M, Romeo G. Characterization of chloride and cation channels in cultured human keratinocytes. Pflugers Arch. 1991 Mar;418(1-2):18-25.

Marchisio PC, Bondanza S, Cremona O, Cancedda R, De Luca M. Polarized expression of integrin receptors (alpha 6 beta 4, alpha 2 beta 1, alpha 3 beta 1, and alpha v beta 5) and their relationship with the cytoskeleton and basement membrane matrix in cultured human keratinocytes. J. Cell Biol. 1991 Feb;112(4):761-73.

Rugolo M, De Luca M, Mastrocola T. Chloride transport pathways in human keratinocytes. Adv Exp Med Biol. 1991;290:297-304; discussion 304-5.

1990

Marchisio PC, Cancedda R, De Luca M. Structural and functional studies of integrin receptors in cultured human keratinocytes. Cell Differ Dev. 1990 Dec 2;32(3):355-9.

De Luca M, Albanese E, Megna M, Cancedda R, Mangiante PE, Cadoni A, Franzi AT. Evidence that human oral epithelium reconstituted in vitro and transplanted onto patients with defects in the oral mucosa retains properties of the original donor site. Transplantation. 1990 Sep;50(3):454-9.

De Luca M, Tamura RN, Kajiji S, Bondanza S, Rossino P, Cancedda R, Marchisio PC, Quaranta V. Polarized integrin mediates human keratinocyte adhesion to basal lamina. Proc Natl Acad Sci U S A. 1990 Sep;87(17):6888-92.

Romagnoli G, De Luca M, Faranda F, Bandelloni R, Franzi AT, Cataliotti F, Cancedda R. Treatment of posterior hypospadias by the autologous graft of cultured urethral epithelium. N Engl J Med. 1990 Aug 23;323(8):527-30.

1989

Raiteri M, Pellegrini G, Cantoni C, Bonanno G. A novel type of GABA receptor in rat spinal cord? Naunyn Schmiedebergs Arch Pharmacol. 1989 Dec;340(6):666-70. doi:10.1007/BF00717742

De Luca M, Albanese E, Bondanza S, Megna M, Ugozzoli L, Molina F, Cancedda R, Santi PL, Bormioli M, Stella M, et al. Multicentre experience in the treatment of burns with autologous and allogenic cultured epithelium, fresh or preserved in a frozen state. Burns. 1989 Oct;15(5):303-9.

Bonanno G, Pellegrini G, Asaro D, Fontana G, Raiteri M. GABAB autoreceptors in rat cortex synaptosomes: response under different depolarizing and ionic conditions. Eur J Pharmacol. 1989 Mar 7;172(1):41-9. doi:10.1016/0922-4106(89)90043-6

Bonanno G, Cavazzani P, Andrioli GC, Asaro D, Pellegrini G, Raiteri M. Release-regulating autoreceptors of the GABAB-type in human cerebral cortex. Br J Pharmacol. 1989 Feb;96(2):341-6. 10.1111/j.1476-5381.1989.tb11823.x

1988

De Luca M, D’Anna F, Bondanza S, Franzi AT, Cancedda R. Human epithelial cells induce human melanocyte growth in vitro but only skin keratinocytes regulate its proper differentiation in the absence of dermis. J Cell Biol. 1988 Nov;107(5):1919-26.

De Luca M, Franzi AT, D’Anna F, Zicca A, Albanese E, Bondanza S, Cancedda R. Coculture of human keratinocytes and melanocytes: differentiated melanocytes are physiologically organized in the basal layer of the cultured epithelium. Eur J Cell Biol. 1988 Apr;46(1):176-80.

D’Anna F, De Luca M, Cancedda R, Zicca A, Franzi AT. Elutriation of human keratinocytes and melanocytes from in vitro cultured epithelium. Histochem. J. (J. Mol. Histol.) 1988;20:674-678.

1987

Pittaluga A, Asaro D, Pellegrini G, Raiteri M. Studies on [3H]GABA and endogenous GABA release in rat cerebral cortex suggest the presence of autoreceptors of the GABAB type. Eur J Pharmacol. 1987 Nov 24;144(1):45-52. doi:10.1016/0014-2999(87)90007-0

Consiglio E. Acquaviva AM, Formisano S, Liguoro D, Gallo A, Vittorio T, Santisteban P, De Luca M, Shifrin S, Yeh HJ et al. Characterization of phosphate residues on thyroglobulin. J Biol Chem. 1987 Jul 25;262(21):10304-14.

Franzi AT, D’Anna F, Zoli S, Albanese E, De Luca M, Cancedda R. [Separation, by elutriation, of human keratinocytes cultured in vitro – article in Italian]. Boll Soc Ital Biol Sper. 1987 May 31;63(5):391-7.

Chan J, Santisteban P, De Luca M, Isozaki O, Grollman E, Kohn L. TSH receptor structure. Acta Endocrinol Suppl (Copenh). 1987;281:166-72.

1986

Kohn LD, Alvarez F, Marcocci C, Kohn AD, Corda D, Hoffman WE, Tombaccini D, Valente WA, De Luca M, Santisteban P, et al. Monoclonal antibody studies defining the origin and properties of autoantibodies in Graves’ disease. Ann N Y Acad Sci. 1986;475:157-73.

Kohn LD, Chan J, Alvarez F, Corda D, Hoffman WE, Kohn AD, Rotella C, Isosaki O, Santisteban P, De Luca M, Grollman EF. Mono-clonal Antibodies to the Thyrotropin (TSH) Receptor in the study of Graves’ Disease: Idiotypes and Antiidiotypes. Clinical Immunology Newsletter. 1986; 7:182-185.

1984

Monaco F, Carducci C, De Luca M, Andreoli M, Dominici R. Human undifferentiated thyroid carcinoma synthesizes and secretes 19S thyroglobulin. Cancer. 1984 Jul 1;54(1):79-83.

1983

Rotella CM, Tanini A, Consiglio E, Shifrin S, De Luca M, Toccafondi R, Kohn LD. Specificity of thyroglobulin interactions with thyroid cells and membranes. Biochem Biophys Res Commun. 1983 Aug 12;114(3):962-8.

1982

Monaco F, De Luca M, Carducci C, Pontecorvi A, D’Armiento M, Roche J. Sur l’inhibition de la biosynthese de la thyroglobuline dans le corps thyroide du rat par l’isoniazide. C R Seances Soc Biol Fil. 1982;176(5):613-8.

Monaco F, Pontecorvi A, De Luca M, De Pirro R, D’Armiento M, Roche J. Inhibition de la biosynthese de la thyroglobuline par le propranolol chez le rat. C R Seances Soc Biol Fil. 1982;176(5):607-12.