Director and Gene Therapy Program Coordinator

ORCID ID orcid.org/0000-0002-0850-8445

ResearcherID N-5883-2014

Scopus Author ID 56082113500 

H-INDEX (Google Scholar): 55

i10-INDEX: 104

Total number of citations (Google Scholar): 14.226

DATE OF BIRTH

May 17, 1956

CURRENT POSITION

  • Full Professor of Biochemistry, University of Modena and Reggio Emilia, Modena, Italy
  • Director, Centre for Regenerative Medicine “Stefano Ferrari”, University of Modena and Reggio Emilia, Modena, Italy
  • Director, Interdepartmental Centre for Stem Cells and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy
  • Scientific Director, Holostem Terapie Avanzate S.r.l., spin-off of the University of Modena and Reggio Emilia, Modena, Italy

EDUCATION

1984 – Specialty in Endocrinology, summa cum laude, University of Rome Medical School. 

1980 – M.D., summa cum laude, University of Catania Medical School.

TRAINING

1985: Visiting scientist at the Department of Physiology and Biophysics, Harvard Medical School (HMS), Boston, MA, USA 

1982-1985: Fogarty Fellow, Section on Biochemistry of Cell Regulation, Laboratory of Biochemical Pharmacology, National Institutes of Arthritis, Diabetes, Digestive and Kidney Diseases (NIADDK), National Institutes of Health (NIH), Bethesda, MD, USA

SCIENTIFIC CAREER

2010-present: Director, Interdepartmental Centre for Stem Cells and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy

2008-present: Scientific Director, Holostem Terapie Avanzate S.r.l., Modena, Italy

2008-present: Director, Centre for Regenerative Medicine “Stefano Ferrari”, University of Modena and Reggio Emilia, Modena, Italy

2004-present: Full Professor of Biochemistry, Department of Life Science, University of Modena and Reggio Emilia, Modena, Italy

2002-2007: Scientific Director, Veneto Eye Bank Foundation, Venice, Italy

1996-2002: Head, Laboratory of Tissue Engineering, Istituto Dermopatico dell’Immacolata (IDI), Roma, Italy

1992-1995: Deputy Head, Laboratory of Cell Differentiation, National Institute for Cancer Research, Genova, Italy

1986-1992: Senior Investigator, Laboratory of Cell Differentiation, National Institute for Cancer Research, Genova, Italy

SUMMARY AND ESSENCE OF SCIENTIFIC ACTIVITY

Michele De Luca has dedicated most of his scientific activities to translational medicine (Stem Cell Reports. 2018). He is recognised as leading scientist in human squamous epithelial stem cell biology aimed at the development of epithelial stem cell-mediated cell therapy and gene therapy. Following on early work on the use of human epidermal stem cell cultures in life-saving treatment of massive full-thickness burns and in repigmentation of stable vitiligo and piebaldism by keratinocyte/melanocyte co-colture (reviewed in Regen. Med. 2006), Michele De Luca and his historic collaborator Graziella Pellegrini, were first to establish human urethral stem cell culture aimed at urethral regeneration in posterior hypospadias (N. Engl. J. Med. 1990). They then developed human limbal stem cell culture (J. Cell Biol. 1999) for corneal regeneration in patients with severe limbal stem cell deficiency (Lancet 1997; N. Engl. J. Med 2010; Regen. Med. 2013). This treatment leads to recovery of normal vision and is now used worldwide. In February 2015 such cultures were formally approved as an Advanced Therapy Medicinal Product by EMA, which registered them under the name of Holoclar. Holoclar is the first stem cell-based therapy approved in Europe and EMA has indicated it amongst the most relevant achiements in the field in the last 20 years.

They have characterised molecular mechanisms regulating long term proliferative potential, clonal evolution and self-renewal of epithelial stem cells. In particular, they shed light on the role of p63 (different isoforms) and c/EBPδ in regulating the proliferative potential and the self-renewal of human corneal stem cells, respectively (PNAS 2001, 2005; J. Cell Biol. 2007). Notably, their work demonstrated that the clinical success of limbal stem cultures is dependent on a discrete number of stem cells identified as holoclones expressing the ΔNα isoform of p63 (N. Engl. J. Med.  2010, TMM 2011, Regen. Med. 2013).

Michele De Luca and Pellegrini is also pioneering ex-vivo epithelial stem cell-mediated gene therapy for genetic skin diseases. He coordinated the first successful clinical trial to treat junctional epidermolysis bullosa (JEB) (Nat. Med. 2006; Stem Cell Rep. 2014; J. Invest. Dermatol, 2017; Nature, 2017).

JEB is a severe, often lethal genetic disease caused by mutations in genes encoding the basement membrane component laminin-332. Surviving JEB patients develop chronic skin and mucosa wounds, which impair their quality of life and lead to skin cancer. De Luca has recently reported life-saving regeneration of the entire, fully functional, epidermis on a 7-year-old child suffering from a devastating, life-threatening form of JEB (Nature, 2017). Using integrations as clonal genetic marks, he has shown that the vast majority of epidermal TA progenitors are progressively lost within a few months after grafting and the regenerated epidermis is indeed sustained only by a limited number of long-lasting, self-renewing stem cells. This notion argues against a model positing the existence of a population of equipotent epidermal progenitors that directly generate differentiated cells during the lifetime of the animal and fosters a model where specific stem cells persist during the lifetime of the human and contribute to both renewal and repair by giving rise to pools of progenitors that persist for various periods of time, replenish differentiated cells and make short-term contribution to wound healing (Nature, 2017). Based on this notion and on the corneal data (N. Engl. J. Med 2010) De Luca and Pellegrini established that the essential feature of any cultured epithelial grafts is the presence (and preservation) of an adequate number of holoclone-forming cells. Their work thus provides a blueprint that can be applied to other stem cell-mediated ex vivo cell and gene therapies (see N&V Nature 2010).

Michele De Luca is internationally recognised for his experience in stem cell therapy and contributed to two reports by the International Society for Stem Cell Research, dealing with new guidelines for responsible translational stem cells research (Cell Stem Cell 2008, 2009).

During the past 30 years, Michele De Luca and Graziella Pellegrini, in collaboration with several clinicians, have treated:

• Approximately 400 patients with massive skin burns (life-saving)

• Over 400 patients with massive ocular burns (restoration of vision)

• Approximately 100 patients with stable vitiligo and piebaldism

• 170 patients with oral mucosa defects

• 18 patients with posterior hypospadias

• current PhaseI/II clinical trials of ex vivo gene therapy of Epidermolysis Bullosa (24 patients enrolled in Italy and Austria)

by means of cultured and highly characterized epithelial stem cells.

NATIONAL AND INTERNATIONAL AWARDS AND RECOGNITIONS

AWARDS

2020 – Louis-Jeantet Prize

2019 – New York Academy of Science & Takeda Pharmaceuticals, “Innovator in Science Award 2019”

2018 – Premio “Lombardia è ricerca” (co-awarded with Tobias Hirsch and Graziella Pellegrini)

2018 – Royan Institute (Teheran), Kazemi Award for Research Excellence in Bio-Medicine

2018 – EURORDIS, Black Pearl Award – Scientific Award (co-awarded with Tobias Hirsch)

2018 – ISSCR, Award for innovation (co-awarded with Graziella Pellegrini)

2017 – The Niche (Knoepfler Lab Blog Stem Cell Blog), Stem Cell Person of the Year Award

2016 – Prix Galien Netherlands 2016 for Holoclar

2016 – Prix Galien United Kingdom 2016 for Holoclar

2016 – UNICEF, Premio Ragno d’Oro

2015 – “Menzione speciale all’innovazione” for Holoclar, Premio Galeno Italia

2015 – Premio Luigi Coppola – Città di Gallipoli

2015 – Comune di Modena, Premio Città di Modena – “Bonissima” awarded by Centre for Regenerative Medicine “Stefano Ferrari”

2015 – Comune di Modena, Premio Città di Modena – “Bonissima” awarded by Holostem Terapie Avanzate

2015 – MIT Technology Review Italia, “Smart & Disruptive Companies 2015” Award to Holostem Terapie Avanzate

2014 – ISSCR, Public Service Award (co-awarded with Paolo Bianco and Elena Cattaneo)

2014 – Comune di Milano, Premio Ambrosoli

2014 – Comune di Padova, Menzione Speciale della giuria scientifica del Premio Galileo per la Divulgazione Scientifica (co-awarded with Paolo Bianco, Elena Cattaneo and Gilberto Corbellini)

2008 – Debra Italia Onlus, Premio Farfalla d’argento

RECOGNITIONS

Life member of the New York Academy of Science

Member of Accademia Nazionale dei Lincei

Member of European Molecular Biology Oragnization (EMBO)

Honorary Member of Associazione degli allievi del Collegio Ghisleri di Pavia

Member of Accademia nazionale di Scienze, Lettere e Arti di Modena

Visit to Italian President Sergio Mattarella, Rome, 16 May 2018

MISCELLANEA

Michele De Luca is member of several scientific societies, several national and international commitees and founding member of the International Ocular Surface Society (IOSS) and of the Stem Cell Research Italy (SCR Italy). Honorary member of’Associazione degli allievi del Collegio Ghisleri di Pavia and ordinary member of of EMBO (European Molecular Biology Organization) and Accademia Nazionale di Scienze, Lettere e Arti di Modena.

Michele De Luca is author of 140 peer reviewed international publications and book chapters and has been invited speaker in approximately 200 international meetings.

Michele De Luca, additional to his academic and scientific activity, has an extensive experience of outreach and communication to the public, including direct engagement with schools and adult audiences, newspaper, radio and TV and has a key role in Italian debate on stem cells and regenerative medicine (http://www.cmr.unimore.it/rassegna_stampa.html). 

TEACHING (COURSES, SEMINARS & WORKSHOPS)

  1. Oxford Stem Cell Institute Symposium, Celebratory Lecture “Sir Richard Gardner”, 1 November 2019, Oxford, UK
  2. 2019 European Summer School, “Stem cell and Regenerative Medicine”, 15-22 September 2019, Hydra, Greece
  3. Institut Pasteur, Advances in Stem Cell Biology Course 2018-2019, 2 July 2019, Paris, France
  4. Scuola di Giornalismo Walter Tobagi, Seminar, 23 May 2019, Milano, Italy
  5. Ordine dei Medici Chirurghi e degli Odontoiatri della Provincia di Modena, Scuola di Etica, Bioetica e Deontologia medica, V course, 12 April 2019, Modena, Italy
  6. ESGCT, European Society of Gene and Cell Therapy Spring School, 3-5 April 2019, Napoli, Italy
  7. Simposium “Nanoengineering for Mechanobiology (N4M), IV edition, 24-27 March 2019, Camogli, Italy
  8. Wellcome Trust/MRC Cambridge Stem Cell Institute, Retreat of the Cambridge Stem Cell Institute, 14-15 March 2019, Cambridge, UK
  9. Università di Teramo, Lezione nella Giornata Annuale di confronto sulle attività di ricerca dei dottorandi regionali del corso di Biotecnologie, 15 February 2019, Teramo, Italy
  10. Università di Foggia, Lezione nel Corso di Laurea internazionale in Scienze e Tecnologie Biomolecolari, Foggia, 14 February 2019, Foggia, Italy
  11. Istituto Tecnico Grazia Deledda, Lezione, 13 February 2019, Lecce, Italy
  12. Accademia dei Lincei, Conferenza di Classe, 8 February 2019, Roma, Italy
  13. Biomedicum Helsinki Seminar series, “Regenerative medicine by somatic stem cells: the paradigm of epithelial stem cells”, 4 February 2019, Helsinki, Finland
  14. University College Dublin, Conway Class Seminar Series, 29 January 2019, Dublin, Ireland
  15. Fondazione Chiara D’Onofrio e Università di Tor Vergata, Lectio magistralis Chiara D’Onofrio 2019, 17 January 2019, Roma, Italy
  16. University of Utrecht, “Introduction to Stem Cell Biology” Course, 10 January 2019, Utrecht, Netherlands
  17. Università di Torino, Scientific Simposium, “New frontiers in Transplantation, Regenerative Medicine and Artificial Life”, 24 November 2018, Torino, Italy
  18. Wellcome Genome Campus, Keynote Speaker, Advanced Course “Genomic for Dermatology”, 19 November 2018, Hinxton, Cambridge, UK
  19. Oxford Stem Cell Institute (OSCI) Annual Symposium, 12-13 November 2018, Oxford, UK
  20. Università degli Studi di Milano, Seminario per gli studenti del corso di Biologia del differenziamento e terapie cellulari, 6 November 2018, Milano, Italy
  21. University of Manchester, MaRMN Seminar, 11 October 2018, Manchester, UK
  22. International Centre for Genetic Engineering and Biotechnology (ICGEB), Seminar “Combined cell and gene therapy of Epidermolysis Bullosa shed light on human epidermal stem cells”, 3 October 2018, Trieste, Italy
  23. Phd Week, Lectio magistralis “Epithelial stem cells in cell and gene therapy”, 25 September 2018, Trieste, Italy
  24. TIGEM, Seminario “Epithelial stem cells in combined cell and gene therapy”, 5 June 2018, Napoli, Italy
  25. Università degli Studi di Cagliari, Seminar “Ricerca Biomedica e Problematiche Etiche, Giuridiche e Sociali”, 17 March 2018, Cagliari, Italy
  26. Fondazione Cassa di Risparmio di Modena, “Into the Future”: Incontro con gli studenti dell’Istituto Formiggini di Sassuolo (MO), 28 March 2018, Modena, Italy
  27. ModenaFondazione Cassa di Risparmio di Modena, “Into the Future”: Incontro con gli studenti dell’Istituto Paradisi di Vignola (MO), 14 March 2018, Modena, Italy
  28. Unistem, X edizione della Giornata della Scienza dedicata alle scuole superiori, 16 March 2018, Modena, Italy
  29. Paul Ehrlich Institute, Seminar, 7 March 2018, Langen, Germany
  30. Fondazione Cassa di Risparmio di Modena, “Into the Future”: Incontro con gli studenti degli Istituti Corni e Fermi di Modena, 5 March 2018, Modena, Italy
  31. Institute for Research in Biomedicine (IRB) Barcelona, Seminar, 23 February 2018, Barcellona, Spain
  32. Accademia Nazionale dei Lincei, Seminar “La terapia genica con cellule staminali per le malattie della pelle”, 19 February 2018, Roma, Italy
  33. Accademia Nazionale Dei Lincei, Centro Linceo Interdisciplinare “Beniamino Segre”, XLV Seminario sulla Evoluzione biologica e i grandi problemi della biologia, “Le Cellule staminali nella medicina rigenerativa e nello sviluppo dei tumori”,19-20 February 2018, Roma, Italy
  34. Massachusetts General Hospital, Seminar, 14 February 2018, Boston, USA
  35. Columbia University, Seminar, 13 February 2018, New York City, USA
  36. Fondazione Cassa di Risparmio di Modena, “Into the Future”: Incontro con gli studenti dell’Istituto Selmi di Modena, 8 February 2018, Modena, Italy
  37. Fondazione Cassa di Risparmio di Modena, “Into the Future”: Incontro con gli studenti dell’Istituto Leonardo da Vinci di Carpi (MO), 1 February 2018, Modena, Italy
  38. Incontro con gli studenti del Liceo Classico Muratori, 25 January 2018, Modena, Italy
  39. Incontro con gli ex-alunni dell’Istituto Selmi, 20 January 2018, Modena, Italy
  40. Università degli Studi di Milano, Seminario per gli studenti del corso di Biologia del differenziamento e terapie cellulari, 2 November 2017, Milano, Italy
  41. 2017 European Summer School, “Stem cell and Regenerative Medicine”, 10-17 September 2017, Hydra, Greece
  42. Associazione Luca Coscioni per la libertà di ricerca scientifica, Comune di Orvieto e Centro studi città di Orvieto, SCOLAR-MENTE: divulgazione del metodo scientifico, 29 April 2017, Orvieto, Italy
  43. ELSA, European Law Students’ Association, Appuntamenti di Biodiritto, “Cellule Staminali: il fiume scientifico e gli argini giuridici”, 10 April 2017, Urbino, Italy
  44. Scuola Superiore Sant’Anna, Lectio magistralis nell’ambito del programma di seminari “Orizzonti in Medicina e Biologia”, 22 March 2017, Pisa, Italy
  45. Unistem, IX edizione della Giornata della Scienza dedicata alle scuole superiori, 17 March 2017, Modena, Italy
  46. Fondazione Cassa di Risparmio di Modena, “Into the Future”: Incontro con gli studenti del Liceo Classico Muratori e del Liceo Classico San Carlo di Modena, 27 March 2017, Modena, Italy
  47. Fondazione Cassa di Risparmio di Modena, “Into the Future”: Incontro con gli studenti dell’Istituto Cavazzi Sorbelli di Pavullo (MO), 15 March 2017, Modena, Italy
  48. Unistem, IX edizione della Giornata della Scienza dedicata alle scuole superiori, 17 March 2017, Modena, Italy
  49. Fondazione Cassa di Risparmio di Modena, “Into the Future”: Incontro con gli studenti dell’Istituto Selmi di Modena, 14 March 2017, Modena, Italy
  50. Fondazione Cassa di Risparmio di Modena, “Into the Future”: Incontro con gli studenti dell’Istituto Fermi di Modena, 13 March 2017, Modena, Italy
  51. Ordine dei Medici di Brescia, Pomeriggi della Medicina, “Cellule della speranza – Le staminali viste con gli occhi della scienza”, 9 March 2017, Brescia, Italy
  52. Giornate della Laicità, incontro con gli studenti del Liceo Scientifico Spallanzani, 4 March 2017, Reggio Emilia, Italy
  53. Fondazione Cassa di Risparmio di Modena, “Into the Future”: Incontro con gli studenti dell’Istituto Volta e del Liceo Scientifico di Scienze Applicate di Sassuolo (MO), 2 March 2017, Modena, Italy
  54. Fondazione Cassa di Risparmio di Modena, “Into the Future”: Incontro con gli studenti del Liceo Formiggini di Sassuolo (MO), 24 February 2017, Modena, Italy
  55. Fondazione Cassa di Risparmio di Modena, “Into the Future”: Incontro con gli studenti del Liceo Classico Muratori, del Liceo Classico San Carlo e del Liceo Scientifico Tassoni di Modena, 8 February 2017, Modena, Italy
  56. Fondazione Cassa di Risparmio di Modena, “Into the Future”: Incontro con gli studenti del Liceo Scientifico Tassoni di Modena, 6 February 2017, Modena, Italy
  57. Associazione Luca Coscioni per la libertà di ricerca scientifica, Comune di Orvieto e Centro studi città di Orvieto, SCOLAR-MENTE: divulgazione del metodo scientifico, 17 December 2016, Orvieto, Italy
  58. Università del Salento, Seminar, 22 November 2016, Lecce, Italy
  59. Accademia Medica di Roma, Giornata in memoria di Paolo Bianco, 10 November 2016, Roma, Italy
  60. Institute of Reconstructive Neurobiology, University of Bonn, LIFE & BRAIN Center, Seminar “State of translational activities at the various sites”, 3 November 2016, Bonn, Germany
  61. Associazione Luca Coscioni per la libertà di ricerca scientifica, Comune di Orvieto e Centro studi città di Orvieto, SCOLAR-MENTE: divulgazione del metodo scientifico (Iniziativa in adesione all’evento Notte dei Ricercatori), 24 September 2016, Orvieto, Italy
  62. EuroStemCell, 2016 European Summer School, “Stem Cells and Regenerative Medicine”, 11-18 September 2016, Hydra, Greece
  63. Scuola di Specializzazione in Malattie dell’Apparato Respiratorio, Summer Meeting 2016, 1 July 2016, Pavullo nel Frignano (MO), Italy
  64. Institut Pasteur & Revive, 4th Advances in Stem Cell Biology Course, 28 June 2016, Paris, France
  65. Università degli Studi di Modena e Reggio Emilia, Incontro con gli studenti sul tema “Il farmaco dalla ricerca di base alla terapia: sinergie tra Accademia e Impresa. Realtà e prospettive occupazionali”, “Cellule staminali e medicina rigenerativa”, 20 May 2016, Modena, Italy
  66. Università degli Studi Federico II, Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Seminario “Epithelial Stem Cells and Regenerative Medicine”, 17 May 2016, Napoli, Italy
  67. Università Federico II di Napoli, Seminario dal titolo “Cellule staminali in medicina rigenerativa: il paradigma delle staminali epiteliali”, 3 May 2016, Napoli, Italy
  68. Università degli Studi di Milano, Seminario per gli studenti del corso di Biologia del differenziamento e terapie cellulari, 18 April 2016, Milano, Italy
  69. Unistem, VIII edizione della Giornata della Scienza dedicata alle scuole superiori, 11 March 2016, Milano, Italy
  70. University of Copenhagen, The Danish Stem Cell Center, DanStem Seminar Series, 16 March 2016, Copenhagen, Denmark
  71. CNR, “Stem Cells: from embryo to therapeutical applications”, 15 February 2016, Roma, Italy
  72. Revive 2016, 4 February 2016, Paris, France
  73. A.S.L. Biella, Ciclo di incontri “La Scienza e le sue frontiere”, “Staminali dalla speranza alla cura per l’epidermolisi bollosa e le lesioni della cornea”, 21 January 2016, Biella, Italy
  74. Università di Modena e Reggio Emilia, Seminario per gli specializzandi in otorinolaringoiatria della Regione Emilia-Romagna, 18 January 2016, Modena, Italy
  75. Collegio Cairoli, Giovedì del collegio Cairoli, “Cellule staminali tra scienza, pseudoscienza ed etica”, 26 November 2015, Pavia, Italy
  76. Collegio Universitario Fondazione San Carlo, Ciclo di Seminari “Etica ed Esperienza: le professioni come luogo di apprendimento morale”, Seminario “Staminali: tra etica, scienza e pseudoscienza”, 29 April 2015, Modena, Italy
  77. Università di Milano, Seminar, 13 April 2015, Milano, Italy
  78. Scuola Superiore di Studi Avanzati Sapienza, Seminar “La Scienza della buona Ricerca Clinica”, Roma, 31 March 2015, Italy
  79. Unistem, VII edizione della Giornata della Scienza dedicata alle scuole superiori, 13 March 2015, Modena, Italy
  80. Università di Catania, Seminar “Epithelial stem cells and regenerative medicine”, European Frontiers in Ocular Pharmacology – Tenth Series,6 March 2015, Catania, Italy
  81. Centre for Integrative Biology, Seminar “Regenerative Medicine by somatic stem cell: the paradigm of epithelial stem cells”,18 December 2014, Trento, Italy
  82. Centre for Regenerative Medicine Therapies TU Dresden, Seminar “Regenerative Medicine by somatic stem cell: the paradigm of epithelial stem cells”, 8 December 2014, Dresden, Germany
  83. XI Hydra Summer School on Stem Cells & Regenerative Medicine, 7-14 September 2014, Hydra, Greece
  84. Università di Catania, Seminar at Scuola Superiore di Catania, 7 July 2014, Catania, Italy
  85. University of Manchester, Seminar “Regenerative Medicine by somatic stem cell: the paradigm of epithelial stem cells”, 27 February 2014, Manchester, UK
  86. UniStem, VI edizione della Giornata della Scienza dedicata alle scuole superiori, 14 March 2014, Modena, Italy
  87. Basel Postdoc Network Retreat 2013, 22-24 July 2013, Arosa, Svizzera
  88. International Centre for Genetic Engineering and Biotechnology (ICGEB), Seminar “Regenerative Medicine by somatic stem cell: the paradigm of epithelial stem cells”, 31 May 2013, Trieste, Italy
  89. Università degli Studi di Catania, Seminar “Cellule staminali epiteliali e medicina rigenerativa”, 29 April 2013, Catania, Italy
  90. UniStem, V edizione della Giornata della Scienza dedicata alle scuole superiori, 15 March 2013, Modena, Italy
  91. European Parliament Information Office in the UK, “Revision of EU Clinical Trials Directive”, 22 February 2013, London, UK
  92. IRCCS Arcispedale Santa Maria Nuova, Seminario “Dai geni, alle cellule, al paziente: successi clinici dalla ricerca traslazionale”, 7 February 2013, Reggio Emilia, Italy
  93. Università degli Studi di Torino, MBC, Molecular Biotechnology Center, Seminar, 15 January 2013, Torino, Italy
  94. Collegio Cairoli, Seminar “Terapia personalizzata con le cellule staminali: la medicina del futuro”, 25 October 2012, Pavia, Italy
  95. ISMETT, Seminar “Cellule staminali epiteliali e medicina rigenerativa”, 22 October 2012, Palermo, Italy
  96. EuroSyStem, Summer School: Stem Cells & Regenerative Medicine, 15-22 September 2012, Hydra, Greece
  97. Stem Cell Research Institute Leuven, Seminar “Regenerative Medicine by somatic stem cell: the paradigm of epithelial stem cells”, 19 March 2012 Leuven, Belgium
  98. University of Zurich, Institute of Anatomy, Seminar “Regenerative Medicine by somatic stem cell: the paradigm of epithelial stem cells”, 12 March 2012, Zurich, Switzerland
  99. UniStem, IV edizione della Giornata della Scienza dedicata alle scuole superiori, 9 March 2012, Modena, Italy
  100. University of Jordan, Seminar, 16 January 2012, Amman, Jordan
  101. Scottish Centre for Regenerative Medicine, Seminar “Epithelial Stem Cells and regenerative Medicine”, 19 December 2011, Edinburgh, UK
  102. Università di Milano, Seminar, 11 November 2011, Milano, Italy
  103. EuroSyStem, Summer School: Stem Cells & Regenerative Medicine, 18-23 September 2011, Hydra, Greece
  104. Institute for Stem Cell Biology & Regenerative Medicine, InStem Frontier Seminar Series, “Epithelial Stem Cell and Regenerative Medicine”, 5-7 September 2011, Bangalore, India
  105. International Centre for Genetic Engineering and Biotechnology (ICGEB), Seminar ” Cellule staminali epiteliali in medicina rigenerativa”, 13 July 2011, Trieste, Italy
  106. Miltenyi Biotec, Symposium “Regenerative medicine and stem cell research, a challenge for the present”, 3 May 2011, Bologna, Italy
  107. BioRep, Incontro “Staminali: e adesso? Ricerca, applicazioni, cure: le nuove frontiere della terapia cellulare”,19 April 2011, Bologna, Italy
  108. UniStem, Giornata su “Cellule Staminali nella sperimentazione clinica”, 24 June 2011, Milano, Italy
  109. Consorzio Italbiotec, “Formazione di ricercatori altamente qualificati nel settore delle Banche di Materiale Biologico per la ricerca, la diagnostica e la clinica”, 12 January 2011, Milano, Italy
  110. Hannover Medical School, Seminar “Epithelial Stem Cells and Regenerative Medicine”, 18 November 2010, Hannover, Germany
  111. National Institutes of Health (NIH), “Epithelial Stem Cell & regenerative Medicine”, 18 October 2010, Bethesda, USA
  112. Stem Cell Summer School for Clinicians, 12-16 July 2010, Cambridge, UK
  113. Università di Catania, Seminar, 6 May 2010, Catania, Italy
  114. Università di Milano-Bicocca, Seminar “Epithelial stem cells and regenerative medicine”, PhD course on Stem Cells, 28 April 2010, Milano, Italy
  115. Università di Napoli, Seminar, 20 April 2010, Napoli, Italy
  116. Università di Napoli, Seminar “Human epithelial stem cells and regenerative medicine”, 1 February 2010, Napoli, Italy
  117. 175th Anniversary, Manchester Medical Society, Telford Memorial Lecture, 27 January 2010, Manchester, UK
  118. Stanford University, Seminar “Human epithelial stem cells and regenerative medicine”, 13 November 2009, Stanford, USA
  119. Università di Milano, Seminar, 4 November 2009, Milano, Italy
  120. EuroSyStem, Summer School: Stem Cells & Regenerative Medicine, 19-25 September 2009, Hydra, Greece
  121. Università di Trieste, Seminar, 2 September 2009, Trieste, Italy
  122. Accademia Nazionale dei Lincei, Seminar “La rigenerazione dei tessuti con le cellule staminali epiteliali”, 26 February 2009, Roma, Italy
  123. UniStem, 6ª Giornata di Studio sulle Cellule Staminali “Terapia genica e cellule staminali”, 30 January 2009, Milano, Italy
  124. Centro Biotecnologie Avanzate (CBA), “Cellule staminali epiteliali in medicina rigenerativa”, 6 November 2008, Genova, Italy
  125. Max Planck Institute of Molecular Cell Biology and Genetics, Seminar, 3 November 2008, Dresda, Germany